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Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis
- Source :
- European Heart Journal, 44(16), 1464-1473. Oxford University Press, University of Bristol-PURE, Elhakeem, A, Taylor, A E, Inskip, H M, Huang, J Y, Mansell, T, Rodrigues, C, Asta, F, Blaauwendraad, S M, Håberg, S E, Halliday, J, Harskamp-van Ginkel, M W, He, J-R, Jaddoe, V W V, Lewis, S, Maher, G M, Manios, Y, McCarthy, F P, Reiss, I K M, Rusconi, F, Salika, T, Tafflet, M, Qiu, X, Åsvold, B O, Burgner, D, Chan, J K Y, Gagliardi, L, Gaillard, R, Heude, B, Magnus, M C, Moschonis, G, Murray, D, Nelson, S M, Porta, D, Saffery, R, Barros, H, Eriksson, J G, Vrijkotte, T G M & Lawlor, D A 2023, ' Long-term cardiometabolic health in people born after assisted reproductive technology : a multi-cohort analysis ', European Heart Journal, vol. 44, no. 16, pp. 1464-1473 . https://doi.org/10.1093/eurheartj/ehac726, European Heart Journal
- Publication Year :
- 2023
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Abstract
- Aims To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age. Methods and results Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance markers were examined using multiple linear regression models in 14 population-based birth cohorts in Europe, Australia, and Singapore, and results were combined using meta-analysis. Change in cardiometabolic outcomes from 2 to 26 years was examined using trajectory modelling of four cohorts with repeated measures. 35 938 (654 ART) offspring were included in the meta-analysis. Mean age ranged from 13 months to 27.4 years but was Conclusion These findings of small and statistically non-significant differences in offspring cardiometabolic outcomes should reassure people receiving ART. Longer-term follow-up is warranted to investigate changes over adulthood in the risks of hypertension, dyslipidaemia, and preclinical and clinical cardiovascular disease.
- Subjects :
- SDG 3 - Good Health and Well-being
Cardiology and Cardiovascular Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 0195668X
- Database :
- OpenAIRE
- Journal :
- European Heart Journal, 44(16), 1464-1473. Oxford University Press, University of Bristol-PURE, Elhakeem, A, Taylor, A E, Inskip, H M, Huang, J Y, Mansell, T, Rodrigues, C, Asta, F, Blaauwendraad, S M, Håberg, S E, Halliday, J, Harskamp-van Ginkel, M W, He, J-R, Jaddoe, V W V, Lewis, S, Maher, G M, Manios, Y, McCarthy, F P, Reiss, I K M, Rusconi, F, Salika, T, Tafflet, M, Qiu, X, Åsvold, B O, Burgner, D, Chan, J K Y, Gagliardi, L, Gaillard, R, Heude, B, Magnus, M C, Moschonis, G, Murray, D, Nelson, S M, Porta, D, Saffery, R, Barros, H, Eriksson, J G, Vrijkotte, T G M & Lawlor, D A 2023, ' Long-term cardiometabolic health in people born after assisted reproductive technology : a multi-cohort analysis ', European Heart Journal, vol. 44, no. 16, pp. 1464-1473 . https://doi.org/10.1093/eurheartj/ehac726, European Heart Journal
- Accession number :
- edsair.doi.dedup.....a7f5efbf6a6a73d8efdc52160dfcf78d