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Enhancement of Chronic Viral Hepatitic Changes by Alcohol Intake in Patients with Persistent HBs-Antigenemia
- Source :
- American Journal of Clinical Pathology. 94:270-273
- Publication Year :
- 1990
- Publisher :
- Oxford University Press (OUP), 1990.
-
Abstract
- The clinical and histologic changes in 116 Japanese patients with persistent HBs-antigenemia and chronic liver diseases were analyzed after the patients were divided into three groups depending on the history of alcohol consumption. Group 1 consisted of 45 nondrinkers, Group 2 of 51 social drinkers, and Group 3 of 20 habitual drinkers with a daily intake of more than 60 g of ethanol for at least ten years. The frequency of chronic active hepatitis (CAH) in Group 3 was higher than in Groups 1 and 2 (P less than 0.05). The histologic comparison of patients with CAH between the three groups revealed that only the inflammatory changes at/near portal tracts, such as piecemeal necrosis and inflammatory cell infiltration in Group 3, were more prominent than those in Groups 1 and 2. The alcohol-related changes except for fatty change were not found in any specimens. These findings suggest that alcohol intake, particularly of more than 60 g of ethanol a day, may enhance the viral inflammatory changes of the liver in patients with persistent HBs-antigenemia.
- Subjects :
- Adult
Male
Piecemeal necrosis
medicine.medical_specialty
Necrosis
Alcohol Drinking
Inflammation
Gastroenterology
chemistry.chemical_compound
Internal medicine
medicine
Humans
In patient
Hepatitis, Chronic
Hepatitis
Hepatitis B Surface Antigens
Ethanol
Chronic Active
business.industry
Liver Diseases
General Medicine
Middle Aged
medicine.disease
chemistry
Immunology
Female
sense organs
Viral disease
medicine.symptom
business
Subjects
Details
- ISSN :
- 19437722 and 00029173
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- American Journal of Clinical Pathology
- Accession number :
- edsair.doi.dedup.....a7f1d9c939fbd6b9d5974e6bedb434f2