Back to Search
Start Over
High resolution optical coherence elastography of retina under prosthetic electrode
- Source :
- Quant Imaging Med Surg, Quantitative imaging in medicine and surgery, vol 11, iss 3
- Publication Year :
- 2021
- Publisher :
- AME Publishing Company, 2021.
-
Abstract
- Background Quantitatively investigating the biomechanics of retina with a retinal prosthetic electrode, we explored the effects of the prosthetic electrode on the retina, and further supplemented data for a potential clinical trial. Methods Biomechanical properties were assessed with a high resolution optical coherence tomography (OCT) based elastography (OCE) system. A shaker was used to initiate elastic waves and an OCT system was used to track axial displacement along with wave propagation. Rabbits received surgery to implant the retinal prosthetic electrode, and elastic wave speed was measured before and after implantation; anatomical B-mode images were also acquired. Results Spatial-temporal maps of each layer in retina with and without prosthetic electrodes were acquired. Elastic wave speed of nerve fiber to inner plexiform layer, inner nuclear to outer nuclear layer, retinal pigmented epithelium layer and choroid to sclera layer without prosthetic electrode were found to be 3.66±0.36, 5.33±0.07, 6.85±0.37, and 9.69±0.24 m/s, respectively. With prosthetic electrode, the elastic wave speed was found to be 4.09±0.26, 5.14±0.11, 6.88±0.70, and 9.99±0.73 m/s, respectively in each layer. Conclusions Our results show that the elastic wave speed in each layer of retina is slightly faster with the retinal electrode, and further demonstrate that the retinal prosthetic electrode does not affect biomechanical properties significantly. In the future, we expect OCE technology to be used by clinicians where it could become part of routine testing and evaluation of the biomechanical properties of the retina in response to long term use of prosthetic electrodes in patients.
- Subjects :
- Materials science
elastic wave propagation
Bioengineering
Optical Physics
Eye
01 natural sciences
010309 optics
03 medical and health sciences
chemistry.chemical_compound
retinal prosthetic electrode
0302 clinical medicine
Optical coherence tomography
Clinical Research
0103 physical sciences
medicine
Radiology, Nuclear Medicine and imaging
Optical coherence elastography
Outer nuclear layer
Eye Disease and Disorders of Vision
mechanical shaker
Retina
Assistive Technology
medicine.diagnostic_test
Rehabilitation
Neurosciences
Retinal
Inner plexiform layer
Condensed Matter Physics
Sclera
Other Physical Sciences
medicine.anatomical_structure
chemistry
Electrode
Original Article
Elastography
sense organs
030217 neurology & neurosurgery
Biomedical engineering
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Quant Imaging Med Surg, Quantitative imaging in medicine and surgery, vol 11, iss 3
- Accession number :
- edsair.doi.dedup.....a7e16dd518c53646afdf2e63e950104f