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Characteristics of Sensitization Associated With Chronic Pain Conditions
- Source :
- The Clinical Journal of Pain. 30:119-128
- Publication Year :
- 2014
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2014.
-
Abstract
- OBJECTIVES To describe and understand varieties and characteristics of sensitization contributing to hyperalgesia in participants with chronic pain conditions. METHODS Thermal stimulation was delivered to the face, forearm, and calf of pain-free participants and individuals with irritable bowel syndrome, temporomandibular pain disorder (TMD), and fibromyalgia syndrome (FM). Three-second contacts by a preheated thermode occurred at 30-second intervals in ascending and then in descending series (0.7°C steps). RESULTS Thermal pain ratings during ascending series were greater at each site in individuals diagnosed with chronic pain. Intense pain at the time of testing further enhanced the ratings at all sites, but mild or moderate clinical pain did not have this effect. Thermal pain in all participants was greater during descending series compared with the ascending series of arm and leg stimulation. The hypersensitivity during the descending series was comparable in pain-free, FM and TMD participants but was increased in duration for arm or leg stimulation of FM participants. DISCUSSION The widespread sensitization for irritable bowel syndrome and TMD participants does not rely on mechanisms of spatial and temporal summation often invoked to explain widespread hyperalgesia associated with chronic pain. Increased sensitivity during descending series of stimulation of an arm or leg but not the face indicates a propensity for sensitization of nociceptive input to the spinal cord. Abnormally prolonged sensitization for FM participants reveals a unique influence of widespread chronic pain referred to deep somatic tissues.
- Subjects :
- Adult
Male
Fibromyalgia
Hot Temperature
Adolescent
Article
Irritable Bowel Syndrome
Young Adult
Widespread Chronic Pain
Psychophysics
medicine
Humans
Irritable bowel syndrome
Sensitization
Aged
Pain Measurement
Pain disorder
business.industry
Temperature
Chronic pain
Nociceptors
Middle Aged
Temporomandibular Joint Disorders
medicine.disease
Anesthesiology and Pain Medicine
medicine.anatomical_structure
Nociception
Hyperalgesia
Anesthesia
Female
Neurology (clinical)
Chronic Pain
medicine.symptom
business
Subjects
Details
- ISSN :
- 07498047
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- The Clinical Journal of Pain
- Accession number :
- edsair.doi.dedup.....a7de4ce6ba4c8fa6816bca39c9f32881