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Hematogones Predict Better Outcome in Allogeneic Hematopoietic Stem Cell Transplantation Irrespective of Graft Sources
- Source :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 24(10)
- Publication Year :
- 2018
-
Abstract
- Benign precursors of B lymphocytes, termed hematogones, are observed in the regenerative state of hematopoiesis following chemotherapy or allogeneic hematopoietic stem cell transplantation (allo-HSCT). Previous studies have demonstrated that expansion of hematogones correlates with better clinical outcomes after allo-HSCT. We retrospectively analyzed the association between hematogones and clinical outcomes in 309 consecutive patients who underwent allo-HSCT, which is the largest population-based cohort reported so far. The incidence of hematogones was significantly higher in complete remission (CR) patients at the time of transplantation than in non-CR patients, after myeloablative conditioning than after reduced-intensity conditioning, with tacrolimus-based graft-versus-host disease (GVHD) prophylaxis than with cyclosporine-based prophylaxis, and with disease other than malignant lymphoma (all P.05). Patients with hematogones developed less acute GVHD and infections than did those without them (P.05). Emergence of hematogones was associated with superior GVHD-free relapse-free survival and lower nonrelapse mortality, and was an independent prognostic factor for overall survival, irrespective of donor sources.
- Subjects :
- Oncology
Adult
Male
medicine.medical_specialty
Transplantation Conditioning
Adolescent
medicine.medical_treatment
Population
Graft vs Host Disease
Hematopoietic stem cell transplantation
Disease-Free Survival
Tacrolimus
03 medical and health sciences
0302 clinical medicine
immune system diseases
Predictive Value of Tests
Internal medicine
Medicine
Humans
education
Aged
Retrospective Studies
Transplantation
Chemotherapy
education.field_of_study
business.industry
Incidence (epidemiology)
Remission Induction
Hematopoietic Stem Cell Transplantation
Hematology
Middle Aged
Allografts
Survival Rate
Haematopoiesis
surgical procedures, operative
030220 oncology & carcinogenesis
Hematologic Neoplasms
Cohort
Cyclosporine
Female
business
030215 immunology
Subjects
Details
- ISSN :
- 15236536
- Volume :
- 24
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
- Accession number :
- edsair.doi.dedup.....a7db15b0bb727c8f1e60bbc93d4777a1