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Prognosis of distal pancreatic cancers controlled by stage
- Source :
- Experimental and Therapeutic Medicine
- Publication Year :
- 2020
- Publisher :
- D.A. Spandidos, 2020.
-
Abstract
- Patients with distal (body/tail) pancreatic cancer have been found to present worse outcome than patients with head cancer, which is generally attributed to the great proportion of advanced stages for body/tail cancers upon detection. However, differences in prognosis between head and body/tail pancreatic cancers controlled by stage have not been analyzed in-depth. In this study, differences in prognosis between head and body/tail pancreatic cancers were examined using the Surveillance, Epidemiology, and End Results Program (SEER) (1973-2014 registry, 85,715 cases). We found that patients with body/tail pancreatic cancer had worse prognosis than patients with head cancer for all combined stages [adjusted hazard ratio (HR), 1.03, 95% confidence interval (CI), 1.00-1.05, P=0.025]. Compared with patients with head cancer, patients with body/tail cancer had lower mortality for stage I cancers (HR, 0.85, 95% CI, 0.76-0.94, P=0.001), no difference in mortality for stages II or III (stage II, HR, 1.00, 95% CI, 0.95-1.06, P=0.965; stage III, 0.97, 95% CI, 0.91-1.04, P=0.398), and higher mortality for stage IV (HR, 1.07, 95% CI, 1.04-1.10, P
- Subjects :
- Cancer Research
medicine.medical_specialty
business.industry
Incidence (epidemiology)
Hazard ratio
Cancer
General Medicine
Articles
medicine.disease
Gastroenterology
Molecular medicine
Confidence interval
Immunology and Microbiology (miscellaneous)
Internal medicine
Pancreatic cancer
Epidemiology
medicine
pancreatic adenocarcinoma
incidence
outcome
prognosis
Stage (cooking)
business
location
Subjects
Details
- Language :
- English
- ISSN :
- 17921015 and 17920981
- Volume :
- 20
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Experimental and Therapeutic Medicine
- Accession number :
- edsair.doi.dedup.....a7da5e8f27d89b64a188257b47672754