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Cancer and cancer survival modulates brain and behavior in a time-of-day-dependent manner in mice
- Source :
- Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
- Publication Year :
- 2019
-
Abstract
- Improvements in breast cancer therapy/diagnosis have substantially increased the cancer survivor population, although many survivors report persistent mental health issues including fatigue, mood and anxiety disorders, and cognitive impairments. These behavioral symptoms impair quality-of-life and are often associated with increased inflammation. Nocturnal rodent models of cancer are critical to the identification of the neurobiological mechanisms underlying these behavioral changes. Although both behavior and immunity display distinct diurnal patterns, most rodent research in this field is performed during the rodents’ inactive (light) period, which could potentially undermine the conclusions and clinical relevance. Therefore, here we tested the extent to which mammary tumors or tumor resection (“survivors”) in mice affects behavior and neuroinflammation in a nyctohemeral (day versus night)-dependent manner. Indeed, only the dark (active) phase unmasked fatigue-like behavior and altered novel object investigation for both tumor-bearing and -resected mice relative to surgical controls. Several inflammatory markers were expressed in a time-of-day-dependent manner (lower in the dark phase) in the blood and brains of surgical control mice, whereas this temporal pattern was absent (IL-1β, CXCL1, Myd88, Cd4) or reversed (C3) in the respective tissues of tumor-bearing and -resected mice. Taken together, these data indicate that the time of day of assessment significantly modulates various persistent and transient tumor-induced behavioral and immune changes.
- Subjects :
- 0301 basic medicine
Time Factors
Population
lcsh:Medicine
Physiology
Inflammation
Anxiety
03 medical and health sciences
Habits
0302 clinical medicine
Breast cancer
Immune system
Cell Line, Tumor
Biomarkers, Tumor
Medicine
Animals
Humans
lcsh:Science
education
Neuroinflammation
Fatigue
Cancer survivor
education.field_of_study
Mice, Inbred BALB C
Multidisciplinary
business.industry
Depression
lcsh:R
Cancer
Brain
Mammary Neoplasms, Experimental
medicine.disease
CXCL1
Disease Models, Animal
030104 developmental biology
lcsh:Q
Female
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific reports
- Accession number :
- edsair.doi.dedup.....a7d69ea594fa0cf3b0c7486e861d2fbf