Mastering bioactive coatings of metal oxide nanoparticles and surfaces through phosphonate dendrons

International audience; We reported herein an efficient method for constructing dendritic bisphosphonic acid tweezers of generations 1 and 2, which have been proven as versatile surface coatings for metal oxides implant or nanoparticles. These procedures delineated a practical and general route to a library of functional dendrons. Several of these dendritic architectures were successfully tested as biocompatible coverings for iron oxide nanoparticles through in vitro assays, but also as antifouling surface coatings for silica through Quartz Crystal Microbalance studies or as stabilizing structure for magnetic nanoparticles-microbubbles conjugates thanks to preliminary Langmuir monolayers studies.