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The Role of Mitochondrial DNA Variation in Age-Related Decline in Gait Speed Among Older Men Living With Human Immunodeficiency Virus
- Publication Year :
- 2018
- Publisher :
- Oxford University Press, 2018.
-
Abstract
- BACKGROUND: Age-related gait speed decline is accelerated in men with human immunodeficiency virus (HIV). Mitochondrial genetic variation is associated with frailty and mortality in the general population and may provide insight into mechanisms of functional decline in people aging with HIV. METHODS: Gait speed was assessed semiannually in the Multicenter AIDS Cohort Study. Mitochondrial DNA (mtDNA) haplogroups were extracted from genome-wide genotyping data, classifying men aged ≥50 years into 5 groups: mtDNA haplogroup H, J, T, Uk, and other. Differences in gait speed by haplogroups were assessed as rate of gait speed decline per year, probability of slow gait speed (
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Male
Aging
Population
Multicenter AIDS Cohort Study
HIV Infections
DNA, Mitochondrial
Haplogroup
Cohort Studies
03 medical and health sciences
Sexual and Gender Minorities
0302 clinical medicine
Risk Factors
Odds Ratio
Medicine
Humans
030212 general & internal medicine
Risk factor
education
Articles and Commentaries
education.field_of_study
business.industry
Age Factors
Genetic Variation
Odds ratio
Middle Aged
Gait
Walking Speed
Preferred walking speed
030104 developmental biology
Infectious Diseases
Logistic Models
Haplotypes
Body Composition
business
Demography
Human mitochondrial DNA haplogroup
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....a7c75b6d2b1a5e38584f4882e14f6919