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Ischemic stroke in a patient with moderate to severe inherited factor VII deficiency
- Source :
- Transfusion and Apheresis Science. 55:364-367
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Thrombosis is known to occur in patients with rare inherited bleeding disorders, usually in the presence of a thrombotic risk factor such as surgery and/or factor replacement therapy, but sometimes spontaneously. We present the case of a 72-year-old African American male diagnosed with congenital factor VII (FVII) deficiency after presenting with ischemic stroke, presumably embolic, in the setting of atherosclerotic carotid artery stenosis. The patient had an international normalized ratio (INR) of 2.0 at presentation, with FVII activity of 6% and normal Extem clotting time in rotational thromboelastometry. He was treated with aspirin (325 mg daily) and clopidogrel (75 mg daily) with no additional bleeding or thrombotic complications throughout his admission. This case provides further evidence that moderate to severe FVII deficiency does not protect against thrombosis.
- Subjects :
- Male
medicine.medical_specialty
Factor VII Deficiency
Inheritance Patterns
030204 cardiovascular system & hematology
Brain Ischemia
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Humans
cardiovascular diseases
Stroke
Aged
Aspirin
Factor VII
business.industry
Hematology
medicine.disease
Clopidogrel
Thrombosis
Surgery
Stenosis
Thromboelastometry
Clotting time
chemistry
Cardiology
Blood Coagulation Tests
business
030215 immunology
medicine.drug
Subjects
Details
- ISSN :
- 14730502
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Transfusion and Apheresis Science
- Accession number :
- edsair.doi.dedup.....a7c2de9dae965be21489c4deabcb8c1d