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MicroRNAs Regulate Bone Development and Regeneration
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 16, Iss 4, Pp 8227-8253 (2015)
- Publication Year :
- 2015
- Publisher :
- MDPI AG, 2015.
-
Abstract
- MicroRNAs (miRNAs) are endogenous small noncoding ~22-nt RNAs, which have been reported to play a crucial role in maintaining bone development and metabolism. Osteogenesis originates from mesenchymal stem cells (MSCs) differentiating into mature osteoblasts and each period of bone formation is inseparable from the delicate regulation of various miRNAs. Of note, apprehending the sophisticated circuit between miRNAs and osteogenic homeostasis is of great value for artificial skeletal regeneration for severe bone defects. In this review, we highlight how different miRNAs interact with diverse osteo-related genes and endeavor to sketch the contours of potential manipulations of miRNA-modulated bone repair.
- Subjects :
- Pathology
medicine.medical_specialty
Cellular differentiation
Review
Bone healing
Biology
Bone and Bones
Catalysis
lcsh:Chemistry
Inorganic Chemistry
bone regeneration
Osteogenesis
microRNA
medicine
Animals
Humans
Regeneration
Physical and Theoretical Chemistry
Bone regeneration
lcsh:QH301-705.5
Molecular Biology
Gene
Spectroscopy
Bone Development
Osteoblasts
Regeneration (biology)
Organic Chemistry
Mesenchymal stem cell
Cell Differentiation
General Medicine
Computer Science Applications
Cell biology
MicroRNAs
lcsh:Biology (General)
lcsh:QD1-999
Homeostasis
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....a7b94f9d66cfe037f174b135e46d5aad