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Beta-catenin-activated hepatocellular adenoma in a male
- Source :
- Clinical journal of gastroenterology. 14(3)
- Publication Year :
- 2020
-
Abstract
- Beta-catenin-activated hepatocellular adenoma is potentially malignant and warrants careful follow-up and surgical resection. Here, we report a 48-year-old man in whom a 55 mm single liver tumor was incidentally detected in the S1 segment. Contrast-enhanced computed tomography scans showed no enhancement in the early phase and a slight defection in the late phase. The tumor was enhanced hyperintensity in the hepatobiliary phase on Gd-ethoxybenzyl-diethylenetriaminepentaacetic acid-enhanced magnetic resonance imaging. The histologic features of ultrasound-guided fine-needle aspiration biopsy indicated hepatocellular adenoma, and the tumor was immunohistochemically positive for glutamine synthetase and β-catenin. Considering the risk of malignant transformation, he underwent laparoscopic-assisted partial liver resection. The resected tumor did not contain any malignant lesions. This case indicates that aspiration needle biopsy and immunohistochemistry were useful for histological diagnosis and treatment decisions based on the molecular definition of hepatocellular adenoma.
- Subjects :
- Male
medicine.medical_specialty
Pathology
Liver tumor
Carcinoma, Hepatocellular
Malignant transformation
Adenoma, Liver Cell
03 medical and health sciences
0302 clinical medicine
Surgical oncology
Internal medicine
medicine
Hepatectomy
Humans
beta Catenin
medicine.diagnostic_test
business.industry
Liver Neoplasms
Gastroenterology
Magnetic resonance imaging
General Medicine
Hepatocellular adenoma
Hepatology
Middle Aged
medicine.disease
Hyperintensity
030220 oncology & carcinogenesis
Immunohistochemistry
030211 gastroenterology & hepatology
business
Subjects
Details
- ISSN :
- 18657265
- Volume :
- 14
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Clinical journal of gastroenterology
- Accession number :
- edsair.doi.dedup.....a7b17a1f29a26efad1ad0135e5129da1