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Effects of genetic background on responses to superovulation in Japanese Black cattle
- Source :
- The Journal of Veterinary Medical Science
- Publication Year :
- 2019
- Publisher :
- Japanese Society of Veterinary Science, 2019.
-
Abstract
- We investigated the effects of genetic background on the responses to superovulation in Japanese Black cattle. The genotype frequencies of GRIA1 and FSHR relating to ovulation and follicular development in each of the major bloodlines—Tajiri, Fujiyoshi, and Kedaka—were analyzed. The Tajiri line had the lowest frequency of G allele homozygosity of c.710A>G in GRIA1 among the three bloodlines, and deviation from Hardy–Weinberg equilibrium was detected. Genotype frequencies of c.337C>G, c.871A>G, and c.1973C>G in FSHR were in Hardy–Weinberg equilibrium in all bloodlines. The results of generalized linear mixed-model analyses showed that farm, levels of plasma anti-Müllerian hormone (AMH) concentration, age in months, repeated superovulation, c.337C>G in FSHR, and bloodlines had significant effects on the responses to superovulation. The number of transferable embryos in the group heterozygous for c.337C>G in FSHR was significantly higher than that in the group homozygous for the C allele. The Kedaka line showed a significantly higher number of ova/embryos, fertilized embryos, and transferable embryos than the Tajiri and Fujiyoshi lines. The concentration of circulating AMH is a useful endocrine marker for antral follicle counts. This study revealed the effects of genetic background on the responses to superovulation using levels of plasma AMH concentration as a covariate. The prominent effect of genetic background on superovulation in the Kedaka line requires additional studies to confirm the genomic regions and polymorphisms that are involved in the trait.
- Subjects :
- Anti-Mullerian Hormone
endocrine system
Genotype
040301 veterinary sciences
media_common.quotation_subject
Biology
Japanese Black cattle
0403 veterinary science
Andrology
03 medical and health sciences
bloodline
FSHR
Polymorphism (computer science)
Follicular phase
GRIA1
Animals
Receptors, AMPA
Allele
Ovulation
030304 developmental biology
media_common
superovulation
0303 health sciences
Full Paper
General Veterinary
04 agricultural and veterinary sciences
Antral follicle
Genotype frequency
Receptors, FSH
Cattle
Female
Theriogenology
Genetic Background
Hormone
Subjects
Details
- ISSN :
- 13477439 and 09167250
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Medical Science
- Accession number :
- edsair.doi.dedup.....a7a572b917113e896ef626077fa70b87