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The PCNA pseudogenes in the human genome
- Source :
- BMC Research Notes, BMC Research Notes, Vol 5, Iss 1, p 87 (2012)
- Publication Year :
- 2012
- Publisher :
- BioMed Central, 2012.
-
Abstract
- Background The proliferating cell nuclear antigen (PCNA) is a key protein in the eukaryotic DNA replication and cell proliferation. Following the cloning and characterisation of the human PCNA gene, the question of the existence of pseudogenes in the human genome was raised. Findings In this short communication we summarise the existing information about the PCNA pseudogenes and critically assess their status. Conclusions We propose the existence of at least four valid PCNA pseudogenes, PCNAP1, PCNAP2, LOC392454 and LOC390102. We would like to recommend assignment of a name for LOC392454 as "proliferating cell nuclear antigen pseudogene 3" (alias PCNAP3) and a name for LOC390102 as "proliferating cell nuclear antigen pseudogene 4" (alias PCNAP4). We prompt for more critical evaluation of the existence of a PCNA pseudogene, designated as PCNAP.
- Subjects :
- Cloning
Genetics
Medicine(all)
biology
Cell growth
Biochemistry, Genetics and Molecular Biology(all)
Pseudogene
lcsh:R
lcsh:Medicine
Eukaryotic DNA replication
General Medicine
Bioinformatics
General Biochemistry, Genetics and Molecular Biology
Proliferating cell nuclear antigen
lcsh:Biology (General)
Correspondence
biology.protein
Human genome
lcsh:Science (General)
Gene
lcsh:QH301-705.5
lcsh:Q1-390
Subjects
Details
- Language :
- English
- ISSN :
- 17560500
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- BMC Research Notes
- Accession number :
- edsair.doi.dedup.....a7a2b251b4792e9d5014cdc6d177faea