Back to Search
Start Over
Effects of pro-inflammatory cytokines and antioxidants expression in the jejunum of mice induced by hydrogen peroxide
- Source :
- International immunopharmacology. 31
- Publication Year :
- 2015
-
Abstract
- Inflammation-induced jejunal cell death and oxidative stress have been observed in inflammatory bowel disease (IBD), but now, there is still no systematic animal model of jejunal oxidative stress for the evaluation of potential therapies. Thus, the purpose of this study was to evaluate the dynamic changes of pro-inflammatory cytokines and antioxidant expression on the jejunal inflammation. In this study, Hydrogen peroxide(H2O2, 10 ml/kg)was administrated intragastrically to mice in a single dose of 1%, 3%, or 5%. The incidence of death, histomorphometry, inflammatory cytokines (including TNF-α,IL-1β,and IL-5), and antioxidant genes were measured via RT-PCR. During the whole period, a massive infiltration of neutrophils was observed in the jejunum. Intragastric administration of H2O2 significantly up-regulated the expression of TNF-α,IL-1β, and IL-5 (P
- Subjects :
- 0301 basic medicine
Programmed cell death
medicine.medical_specialty
Antioxidant
medicine.medical_treatment
Immunology
Inflammation
medicine.disease_cause
Inflammatory bowel disease
Antioxidants
Proinflammatory cytokine
Jejunum
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
Internal medicine
medicine
Immunology and Allergy
Animals
Humans
Hydrogen peroxide
Pharmacology
Mice, Inbred ICR
business.industry
Hydrogen Peroxide
medicine.disease
Inflammatory Bowel Diseases
Disease Models, Animal
Oxidative Stress
030104 developmental biology
medicine.anatomical_structure
Endocrinology
chemistry
Gene Expression Regulation
030220 oncology & carcinogenesis
Cytokines
Female
medicine.symptom
Inflammation Mediators
business
Oxidative stress
Subjects
Details
- ISSN :
- 18781705
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- International immunopharmacology
- Accession number :
- edsair.doi.dedup.....a7a031321e8192ce4965a98b3c1dee98