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The Associations between Circulating Bile Acids and the Muscle Volume in Patients with Non-alcoholic Fatty Liver Disease (NAFLD)
- Source :
- Internal Medicine
- Publication Year :
- 2017
- Publisher :
- Japanese Society of Internal Medicine, 2017.
-
Abstract
- Objective Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity, dyslipidemia and type-2 diabetes mellitus. Bile acids (BAs) bind to the farnesoid X receptor (FXR) and G protein-coupled receptor 5 (TGR5), which are involved in lipid and glucose metabolism and energy expenditure. The present study aimed to determine associations between the circulating BAs and the skeletal muscle volume (SMV), and lipid and glucose metabolism in patients with NAFLD. Methods Serum BAs and metabolic parameters were measured in 55 patients with NAFLD (median age, 55 years). The changes (Δ) in serum BA (ΔBA) and metabolic parameters were determined in 17 patients (male, n=10; female, n=7) who received nutritional counseling for 12 months. Results Spearman's test revealed that the levels of 12α-hydroxysterol (12α-OH) BAs, including deoxycholic acid (DCA), were inversely correlated with the SMV of the upper and lower limbs and the total SMV. A multivariate analysis revealed that the level of DCA was correlated with a reduced total SMV, whereas non-12α-OH BAs, including chenodeoxycholic acid (CDCA), were correlated with an increased SMV of the lower limbs. Changes in CDCA were positively correlated with the ΔSMV of the lower limbs, and inversely correlated with the Δwaist-hip ratio and Δtotal cholesterol. Changes in the total non-12α-OH BA level were positively correlated with the ΔSMV of the lower limbs. Conclusion Circulating BAs were associated with SMV. The 12α-OH BAs, including DCA were associated with reduced SMV levels, whereas non-12α-OH BAs including CDCA were associated with increased SMV levels. The molecular mechanisms underlying the association between the BA levels and the SMV remain to be explored.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
education
Chenodeoxycholic Acid
Receptors, G-Protein-Coupled
Bile Acids and Salts
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Non-alcoholic Fatty Liver Disease
insulin resistance
Internal medicine
Chenodeoxycholic acid
Diabetes mellitus
Internal Medicine
medicine
Humans
Muscle, Skeletal
business.industry
Cholesterol
Deoxycholic acid
Fatty liver
RNA-Binding Proteins
General Medicine
Middle Aged
Lipid Metabolism
medicine.disease
G protein-coupled bile acid receptor
Glucose
030104 developmental biology
Endocrinology
Liver
chemistry
cholesterol metabolism
Female
Original Article
030211 gastroenterology & hepatology
Farnesoid X receptor
G-protein-coupled bile acid receptor 5
waist-hip ratio
Energy Metabolism
business
farnesoid X receptor
Dyslipidemia
Deoxycholic Acid
Subjects
Details
- ISSN :
- 13497235 and 09182918
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Internal Medicine
- Accession number :
- edsair.doi.dedup.....a79b95542f577d1a118ef21901e0e76f