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Obesity, Peroxisome Proliferator-Activated Receptor, and Atherosclerosis in Type 2 Diabetes

Authors :
Willa A. Hsueh
Ronald E. Law
Florian Blaschke
Evren Caglayan
Yasunori Takata
Source :
Arteriosclerosis, Thrombosis, and Vascular Biology. 26:28-40
Publication Year :
2006
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2006.

Abstract

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. The 3 PPAR isotypes, PPAR-α, PPAR-γ, and PPAR-δ, play a key role in the regulation of lipid and glucose metabolism. Obesity and the interrelated disorders of the metabolic syndrome have become a major worldwide health problem. In this review, we summarize the critical role of PPARs in regulating inflammation, lipoprotein metabolism, and glucose homeostasis and their potential implications for the treatment of obesity, diabetes, and atherosclerosis.

Details

ISSN :
15244636 and 10795642
Volume :
26
Database :
OpenAIRE
Journal :
Arteriosclerosis, Thrombosis, and Vascular Biology
Accession number :
edsair.doi.dedup.....a7909d776746f41e31ed1b13e83866fb
Full Text :
https://doi.org/10.1161/01.atv.0000191663.12164.77