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Obesity, Peroxisome Proliferator-Activated Receptor, and Atherosclerosis in Type 2 Diabetes
- Source :
- Arteriosclerosis, Thrombosis, and Vascular Biology. 26:28-40
- Publication Year :
- 2006
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2006.
-
Abstract
- Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. The 3 PPAR isotypes, PPAR-α, PPAR-γ, and PPAR-δ, play a key role in the regulation of lipid and glucose metabolism. Obesity and the interrelated disorders of the metabolic syndrome have become a major worldwide health problem. In this review, we summarize the critical role of PPARs in regulating inflammation, lipoprotein metabolism, and glucose homeostasis and their potential implications for the treatment of obesity, diabetes, and atherosclerosis.
- Subjects :
- chemistry.chemical_classification
medicine.medical_specialty
Peroxisome proliferator
business.industry
Vascular disease
Peroxisome Proliferator-Activated Receptors
Peroxisome proliferator-activated receptor
Nutritional status
Type 2 diabetes
Atherosclerosis
medicine.disease
Obesity
Endocrinology
Diabetes Mellitus, Type 2
chemistry
Internal medicine
Diabetes mellitus
Animals
Humans
Medicine
lipids (amino acids, peptides, and proteins)
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15244636 and 10795642
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Accession number :
- edsair.doi.dedup.....a7909d776746f41e31ed1b13e83866fb
- Full Text :
- https://doi.org/10.1161/01.atv.0000191663.12164.77