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Chemoprevention of Head and Neck Cancers: Does It Have Only One Face?
- Source :
- BioMed Research International, Vol 2018 (2018), BioMed Research International
- Publication Year :
- 2018
- Publisher :
- Hindawi Limited, 2018.
-
Abstract
- Head and neck squamous cell cancer (HNSCC) represents a significant burden worldwide. Chemoprevention of HNSCC is a means of cancer control with a use of drugs or natural agents in order to hinder or delay the cancer development. The purpose of this article is to review mechanism of action of different chemopreventive agents’ groups and results of most important researches concerning them. The safety issues of HNSCC chemoprevention are also discussed. In case of HNSCC there is currently no agent, which would give positive result in the third phase of clinical trials. Promising results of preclinical trials are not always confirmed by further tests. Main problems are low effectiveness, high toxicity, and lack of highly specificity biomarkers for monitoring the research. New trials concerning many agents, as well as novel technologies for provision of pharmaceutical forms of them, including drug nanocarriers, are currently underway, which gives hope for finding the perfect chemopreventive agent formula.
- Subjects :
- 0301 basic medicine
Oncology
Drug
medicine.medical_specialty
media_common.quotation_subject
lcsh:Medicine
Antineoplastic Agents
Review Article
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Cancer control
Internal medicine
medicine
Humans
Head and neck
media_common
Drug Carriers
Squamous cell cancer
General Immunology and Microbiology
business.industry
lcsh:R
General Medicine
Clinical trial
stomatognathic diseases
030104 developmental biology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Nanoparticles
Cancer development
Nanocarriers
business
Subjects
Details
- ISSN :
- 23146141 and 23146133
- Volume :
- 2018
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....a78879522701771b468effee1c761f22
- Full Text :
- https://doi.org/10.1155/2018/9051854