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Chemoprevention of Head and Neck Cancers: Does It Have Only One Face?

Authors :
Mariola Dorecka
Jarosław Markowski
Wirginia Likus
Renata Wilk
Włodzimierz Dziubdziela
Krzysztof Siemianowicz
Source :
BioMed Research International, Vol 2018 (2018), BioMed Research International
Publication Year :
2018
Publisher :
Hindawi Limited, 2018.

Abstract

Head and neck squamous cell cancer (HNSCC) represents a significant burden worldwide. Chemoprevention of HNSCC is a means of cancer control with a use of drugs or natural agents in order to hinder or delay the cancer development. The purpose of this article is to review mechanism of action of different chemopreventive agents’ groups and results of most important researches concerning them. The safety issues of HNSCC chemoprevention are also discussed. In case of HNSCC there is currently no agent, which would give positive result in the third phase of clinical trials. Promising results of preclinical trials are not always confirmed by further tests. Main problems are low effectiveness, high toxicity, and lack of highly specificity biomarkers for monitoring the research. New trials concerning many agents, as well as novel technologies for provision of pharmaceutical forms of them, including drug nanocarriers, are currently underway, which gives hope for finding the perfect chemopreventive agent formula.

Details

ISSN :
23146141 and 23146133
Volume :
2018
Database :
OpenAIRE
Journal :
BioMed Research International
Accession number :
edsair.doi.dedup.....a78879522701771b468effee1c761f22
Full Text :
https://doi.org/10.1155/2018/9051854