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Study to Improve Cardiovascular Outcomes in high-risk older patieNts (ICON1) with acute coronary syndrome: study design and protocol of a prospective observational study
- Source :
- BMJ Open
- Publication Year :
- 2016
- Publisher :
- BMJ, 2016.
-
Abstract
- Introduction The ICON1 study (a study to Improve Cardiovascular Outcomes in high-risk older patieNts with acute coronary syndrome) is a prospective observational study of older patients (≥75 years old) with non-ST-elevation acute coronary syndrome managed by contemporary treatment (pharmacological and invasive). The aim of the study was to determine the predictors of poor cardiovascular outcomes in this age group and to generate a risk prediction tool. Methods and analysis Participants are recruited from 2 tertiary hospitals in the UK. Baseline evaluation includes frailty, comorbidity, cognition and quality-of-life measures, inflammatory status assessed by a biomarker panel, including microRNAs, senescence assessed by telomere length and telomerase activity, cardiovascular status assessed by arterial stiffness, endothelial function, carotid intima media thickness and left ventricular systolic and diastolic function, and coronary plaque assessed by virtual histology intravascular ultrasound and optical coherence tomography. The patients are followed-up at 30 days and at 1 year for primary outcome measures of death, myocardial infarction, stroke, unplanned revascularisation, bleeding and rehospitalisation. Ethics and dissemination The study has been approved by the regional ethics committee (REC 12/NE/016). Findings of the study will be presented in scientific sessions and will be published in peer-reviewed journals. Trial registration number NCT01933581: Pre-results.
- Subjects :
- Acute coronary syndrome
medicine.medical_specialty
Comorbidity
Cardiovascular Medicine
030204 cardiovascular system & hematology
acute coronary syndrome
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Protocol
Humans
Medicine
Prospective Studies
030212 general & internal medicine
Myocardial infarction
Prospective cohort study
Stroke
Aged
Proportional Hazards Models
Ultrasonography
Aged, 80 and over
Frailty
business.industry
Study design
General Medicine
medicine.disease
older patients
Treatment Outcome
England
Intima-media thickness
Research Design
Quality of Life
Arterial stiffness
Physical therapy
Observational study
business
Biomarkers
Tomography, Optical Coherence
Subjects
Details
- ISSN :
- 20446055
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- BMJ Open
- Accession number :
- edsair.doi.dedup.....a7851a02c3c7cb3ad9e8f68e44d11658