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Aronia melanocarpa fruit juice ameliorates the symptoms of inflammatory bowel disease in TNBS-induced colitis in rats
- Source :
- Food and Chemical Toxicology. 113:33-39
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Trinitrobenzensulfonic acid (TNBS) is commonly used to induce an experimental inflammatory bowel disease (IBD) model. Oxidative stress and inflammation have been proposed as mechanisms underlying the pathophysiology of IBD. Aronia melanocarpa fruit juice (AMFJ) is extremely rich in polyphenolic substances, mainly proanthocyanidins, flavonoids and phenolic acids. The aim of this study was to evaluate the effect of AMFJ in a rat TNBSinduced colitis model and to compare the effect of the juice with that of sulfasalazine. Colitis was induced by TNBS in male Wistar rats. After the induction of colitis, AMFJ at three doses (2.5, 5 and 10 mL/kg) and sulfasalazine (400 mg/kg) were administered orally till the 14th experimental day. Severity of colitis was assessed by macroscopic and histopathological criteria. Oxidative stress was evaluated by the concentration of thiobarbituric acid reactive substances (TBARS). TNBS caused severe colonic damage. AMFJ dose-dependently ameliorated TNBS-induced colitis. It improved the macroscopic and microscopic signs of colitis, and prevented the increase of colonic TBARS concentrations. Regarding different indices, the effect of AMFJ was comparable or even higher than that of sulfasalazine. In conclusion, the ameliorative effects of AMFJ in the experimental TNBSinduced colitis might be the result of its potent antioxidant and antiinflammatory properties.
- Subjects :
- Male
Antioxidant
Thiobarbituric acid
medicine.medical_treatment
Anti-Inflammatory Agents
Inflammation
Pharmacology
Toxicology
medicine.disease_cause
Thiobarbituric Acid Reactive Substances
Inflammatory bowel disease
Antioxidants
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Sulfasalazine
Photinia
medicine
TBARS
Animals
Rats, Wistar
Colitis
Plant Extracts
business.industry
General Medicine
Inflammatory Bowel Diseases
medicine.disease
digestive system diseases
Rats
Fruit and Vegetable Juices
Disease Models, Animal
Trinitrobenzenesulfonic Acid
chemistry
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
medicine.symptom
business
Oxidative stress
Food Science
medicine.drug
Subjects
Details
- ISSN :
- 02786915
- Volume :
- 113
- Database :
- OpenAIRE
- Journal :
- Food and Chemical Toxicology
- Accession number :
- edsair.doi.dedup.....a77b7cb7117608c7557b6296e54b5c99
- Full Text :
- https://doi.org/10.1016/j.fct.2018.01.011