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Investigation of developmental and reproductive effects of resveratrol in Drosophila melanogaster
- Source :
- Toxicol Res (Camb)
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- © 2021 The Author(s). Published by Oxford University Press. All rights reserved.Resveratrol is a chemical that attracts attention due to its antioxidative, anti-inflammatory, and estrogenic/antiestrogenic properties. In the present study, it was aimed to investigate developmental and reproductive effects (developmental periods, average numbers of offspring, sex ratios) of resveratrol in Drosophila melanogaster. Their larvae were exposed to 50, 100, and 200 μM of resveratrol. Resveratrol treatments did not affect pupation and maturation rate (P > 0.05) statistically. But the pupation and maturation times were significantly extended at all doses (P < 0.05). Also, 100 and 200 μM resveratrol treatments resulted in a significant decrease in the number of offspring (P < 0.05). The results reveal that resveratrol, which is generally known for its positive effects, may have negative effects on the development and reproduction of invertebrates. The results of this study support the idea that resveratrol may act as an endocrine disruptor, as it is a phytoestrogen.
- Subjects :
- Paper
Developmental toxicity
Reproductive toxicity
Drosophila melanogaster
endocrine system diseases
Resveratrol
organic chemicals
Health, Toxicology and Mutagenesis
Endocrine disrupting compounds
food and beverages
skin and connective tissue diseases
Toxicology
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 20454538
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Toxicology Research
- Accession number :
- edsair.doi.dedup.....a76858d54922d5a845c4fb4441d552c3