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Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two caucasian populations
- Source :
- Prostaglandins, Leukotrienes and Essential Fatty Acids, 89(5), 297-303. Churchill Livingstone, Vinknes, K J, Dekker, J M, Drevon, C A, Refsum, H, Nurk, E, Nijpels, G, Stehouwer, C D A, Teerlink, T, Tell, G S, Nygard, O, Vollset, S E, Ueland, P M & Elshorbagy, A K 2013, ' Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two caucasian populations ', Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 89, no. 5, pp. 297-303 . https://doi.org/10.1016/j.plefa.2013.09.007, Prostaglandins Leukotrienes and Essential Fatty Acids, 89(5), 297-303. ELSEVIER SCI LTD
- Publication Year :
- 2013
- Publisher :
- ELSEVIER SCI LTD, 2013.
-
Abstract
- In rats, dietary restriction of the cysteine precursor methionine suppresses hepatic stearoyl-CoA desaturase (SCD)-1 expression and activity, whereas cysteine supplementation reverses these effects. In 2 independent cohorts: Hordaland Health Study (HUSK; N=2021, aged 71-74y), Norway, and Hoorn study (N=686, aged 50-87y), Netherlands, we examined the cross-sectional associations of plasma sulfur-containing compounds (SCC; methionine, S-adenosylmethionine, S-adenosylhomocysteine, homocysteine, cystathionine, total cysteine (tCys), glutathione and cysteinylglycine) with SCD-16 index (16:1n-7/16:0), estimated from fatty acid profiles of total plasma or serum lipids. Only tCys was consistently associated with SCD-16 index after adjustments for sex and age (HUSK: partial r=0.14; Hoorn: partial r=0.11, P
- Subjects :
- Male
medicine.medical_specialty
S-Adenosylmethionine
Homocysteine
Clinical Biochemistry
Sulfur amino acids
White People
Cohort Studies
chemistry.chemical_compound
Animal data
Cystathionine
Methionine
Internal medicine
Surveys and Questionnaires
medicine
Humans
Cysteine
Exercise
Aged
chemistry.chemical_classification
Aged, 80 and over
biology
Chemistry
Fatty Acids
Fatty acid
Cell Biology
Glutathione
Dipeptides
Middle Aged
Cystathionine beta synthase
S-Adenosylhomocysteine
Diet
Stearoyl-CoA desaturase
Stearoyl-CoA Desaturase
Amino Acids, Sulfur
Endocrinology
Cross-Sectional Studies
Biochemistry
Adipose Tissue
Fatty acid profile
biology.protein
Female
Subjects
Details
- Language :
- English
- ISSN :
- 09523278
- Volume :
- 89
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Prostaglandins Leukotrienes and Essential Fatty Acids
- Accession number :
- edsair.doi.dedup.....a7605dffbc2e7aee3087ff7e3f261f9b