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Synergistic or Antagonist Effects of Different UV Ranges Analyzed by the Combination Index: Application to DNA Photoproducts
- Source :
- Photochemistry and Photobiology, Photochemistry and Photobiology, Wiley, In press, ⟨10.1111/php.13528⟩, Photochemistry and Photobiology, inPress, ⟨10.1111/php.13528⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- International audience; Photobiological effects are known to greatly depend on the wavelength of the incident photons that define the nature of the activated chromophores. A growing number of experimental data show that considering the effect of complex light sources as a sum of the effects of monochromatic exposures can be misleading. Indeed, the combined exposure to several wavelength ranges may modulate photobiological responses or even induce novel processes. These observations are similar to a well known topic in chemical toxicology: the non additivity of effects in mixtures where either antagonism or synergy are often observed. In the present work, we investigated if a data analysis tool first developed for studying non-additivity in mixtures of drugs, the combination index, could be applied to photobiological processes. We chose to work on the formation of UV induced DNA photoproducts where additive, antagonist and synergistic effects take place simultaneously. In addition to this application, we worked on the mathematical bases of the concept in order to broaden its applicability to phenomena exhibiting various dose response patterns. We also addressed the question of the evaluation of the error on the determination of the combination index.
- Subjects :
- Ultraviolet Rays
010402 general chemistry
01 natural sciences
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
Physical and Theoretical Chemistry
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
non-additive effects
030304 developmental biology
0303 health sciences
Photons
co-exposure
action spectra
Antagonist
Combination index
General Medicine
DNA
Photobiology
0104 chemical sciences
chemistry
DNA damage
Co exposure
Biological system
data modeling
Subjects
Details
- Language :
- English
- ISSN :
- 00318655
- Database :
- OpenAIRE
- Journal :
- Photochemistry and Photobiology, Photochemistry and Photobiology, Wiley, In press, ⟨10.1111/php.13528⟩, Photochemistry and Photobiology, inPress, ⟨10.1111/php.13528⟩
- Accession number :
- edsair.doi.dedup.....a760234abb6ffe892d9f32eae0b75fde