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Quantification of Ocular Biomechanics In Ocular Manifestations of Systemic Autoimmune Diseases
- Source :
- Ocular immunology and inflammation. 27(7)
- Publication Year :
- 2018
-
Abstract
- Purpose: To quantify biomechanical change associated with autoimmune diseases using Corvis ST deformation data. Methods: Cross-sectional, observational, case control study of 76 patients with systemic autoimmune disease and 21 control subjects. All patients underwent detailed ophthalmic examination with Corvis-ST (Oculus Optikgerate Gmbh, Germany) measurements for biomechanical properties of the eye. Corneal deformation and also deformation caused by the extracorneal tissue were recorded. Using a mathematical formula, the three parameters, namely, corneal stiffness (kc), extracorneal tissue stiffness (kg), and extracorneal tissue viscosity (μg), were defined. Results: The biomechanical analysis showed that kc and μg were significantly lower in patients with systemic autoimmune disease with eye manifestations than control group. However statistically, it was significant in rheumatoid arthritis (RA) patients only. Conclusion: The new parameters, namely, kc, kg, and μg, can provide a sensitive marker of the ocular activity of the collagen vascular diseases.
- Subjects :
- Adult
Male
medicine.medical_specialty
0206 medical engineering
02 engineering and technology
Eye Manifestations
Slit Lamp Microscopy
Autoimmune Diseases
Corneal Diseases
Cornea
03 medical and health sciences
0302 clinical medicine
Ophthalmology
medicine
Immunology and Allergy
Humans
In patient
Corneal deformation
Intraocular Pressure
Retrospective Studies
Ankylosing spondylitis
business.industry
Case-control study
Biomechanics
medicine.disease
020601 biomedical engineering
Elasticity
Ophthalmoscopy
Cross-Sectional Studies
Rheumatoid arthritis
030221 ophthalmology & optometry
Female
Sarcoidosis
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 17445078
- Volume :
- 27
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Ocular immunology and inflammation
- Accession number :
- edsair.doi.dedup.....a74a3264a34feba4ff45c8ced6a37803