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Salivary Inflammatory Mediator Profiling and Correlation to Clinical Disease Markers in Asthma
- Source :
- PLoS ONE, Vol 9, Iss 1, p e84449 (2014), PLoS ONE
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- Rationale There is a need for a readily available, non-invasive source of biomarkers that predict poor asthma control. Objectives We sought to determine if there is an association between the salivary inflammatory profile and disease control in children and adults with asthma. Methods In this cross-sectional study, we collected demographic and clinical information from two independent populations at different sites, resulting in convenience samples of 58 pediatric and 122 adult urban asthmatics. Control was assessed by symptom questionnaire (children) and by Asthma Control Questionnaire and current exacerbation (adults). Saliva was collected in all subjects. We applied principal component analysis to a 10-plex panel of relevant inflammatory markers to characterize marker profiles and determined if profiles were associated with asthma control. Results There were similar, strong correlations amongst biologically related markers in both populations: eosinophil-related: eotaxin-1/CCL11, RANTES/CCL5, and IL-5 (p
- Subjects :
- Male
Saliva
Myeloid
Pulmonology
Exacerbation
Epidemiology
lcsh:Medicine
Correlation
Pathology
Child
lcsh:Science
CCL11
Principal Component Analysis
Multidisciplinary
Age Factors
Middle Aged
3. Good health
medicine.anatomical_structure
Asthma Control Questionnaire
Child, Preschool
Medicine
Cytokines
Female
Inflammation Mediators
Research Article
Adult
medicine.medical_specialty
Adolescent
Diagnostic Medicine
Internal medicine
medicine
Humans
Asthma
business.industry
lcsh:R
Immunologic Subspecialties
Eosinophil
Nasal Lavage Fluid
medicine.disease
Patient Outcome Assessment
Biomarker Epidemiology
Immune System
Immunology
Clinical Immunology
lcsh:Q
business
Pulmonary Immunology
Biomarkers
General Pathology
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....a7385c23770eeb4021d79ada2c9d363b
- Full Text :
- https://doi.org/10.1371/journal.pone.0084449