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Efficacy Of A Quadrivalent Rhesus Rotavirus-Based Human Rotavirus Vaccine Aimed At Preventing Severe Rotavirus Diarrhea In Infants And Young Children
- Source :
- Journal of Infectious Diseases. 174:S65-S72
- Publication Year :
- 1996
- Publisher :
- Oxford University Press (OUP), 1996.
-
Abstract
- The most extensively explored strategy for rotavirus vaccination has been the Jennerian approach, which uses an antigenically related rotavirus strain from an animal host as the immunogen to induce protection against the 4 epidemiologically important group A rotavirus VP7 serotypes. Because this approach has shown limited efficacy, a modified Jennerian approach was developed with the goal of achieving broader antigenic coverage. Four VP7 serotypes were incorporated into a quadrivalent vaccine comprised of three rhesus-human rotavirus reassortants, each with 10 rhesus rotavirus genes and 1 human rotavirus gene that encodes VP7 serotype 1, 2, or 4 specificity ; the rhesus rotavirus itself provides coverage for VP7 serotype 3. This approach appears quite promising for preventing severe rotavirus diarrhea, including those episodes that lead to dehydration. Additional strategies under development stress the role not only of human rotavirus VP7 but also of human rotavirus VP4, the other outer capsid protein that also induces neutralizing antibodies.
- Subjects :
- Diarrhea
Rotavirus
Serotype
Immunogen
viruses
Vaccines, Attenuated
medicine.disease_cause
Group A
Rotavirus Infections
Capsid
fluids and secretions
Antigen
medicine
Animals
Humans
Immunology and Allergy
Antigens, Viral
Clinical Trials as Topic
biology
business.industry
Infant, Newborn
Rotavirus Vaccines
Infant
virus diseases
Viral Vaccines
Macaca mulatta
Virology
Infectious Diseases
Child, Preschool
Immunology
biology.protein
Capsid Proteins
medicine.symptom
Antibody
business
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 174
- Database :
- OpenAIRE
- Journal :
- Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....a71e383e93f47f707df5cfafae4c06ba