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Comparative studies on the camptothecin content from Nothapodytes foetida and Ophiorrhiza species
- Source :
- Natural product research. 20(1)
- Publication Year :
- 2005
-
Abstract
- Camptothecin is an anticancer quinoline alkaloid effective against colon cancer. It acts by inhibition of the enzyme DNA topoisomerase I. A comparative study of camptothecin from the indigenous plants namely Nothapodytes foetida, Ophiorrhiza mungos and Ophiorrhiza rugosa indicated highest yields of camptothecin and 9-methoxy camptothecin in N. foetida. The other two plants O. mungos and O. rugosa contained low levels of alkaloids.
- Subjects :
- Rubiaceae
Plant Science
Biochemistry
Analytical Chemistry
Ophiorrhiza mungos
chemistry.chemical_compound
Magnoliopsida
Species Specificity
Botany
polycyclic compounds
medicine
heterocyclic compounds
Medicinal plants
neoplasms
Chromatography, High Pressure Liquid
biology
Alkaloid
Organic Chemistry
Quinoline
biology.organism_classification
Ophiorrhiza
chemistry
Nothapodytes foetida
Camptothecin
Spectrophotometry, Ultraviolet
biological phenomena, cell phenomena, and immunity
Mungos
medicine.drug
Subjects
Details
- ISSN :
- 14786419
- Volume :
- 20
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Natural product research
- Accession number :
- edsair.doi.dedup.....a71c8af1f7c9d3e9c391cf58df028704