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Circulating progenitor cells: a comparison of patients with glioblastoma or meningioma
- Source :
- Acta Neurologica Belgica. 113:7-11
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- Blood circulating endothelial cells and circulating hematopoietic progenitor cells (CPCs) are two cell populations that are thought to play important role in angiogenesis. In the present study, we investigated the role of CPCs in patients with brain tumors. We prospectively studied 19 brain tumor patients. Ten healthy individuals were used as controls. Variables that were analyzed included age, sex, Ki-67 index, symptom duration, tumor location, tumor size and preoperative Karnofsky performance status score (KPS). CPCs were determined as CD45(dim)/CD34+/CD133+ in the peripheral blood. Twelve patients had glioblastoma (GBM), 1 patient had a grade II glioma and 6 patients had meningioma. Brain tumor patients had significantly higher CPC levels compared to healthy volunteers. Patients with gliomas had significantly higher CPC levels than patients with meningiomas. In GBM patients no correlation was found between CPC levels and sex, age, Ki-67 index, tumor location, size and KPS. Patients with CPC levels lower than 1,743 cells/ml had a higher progression-free survival but the difference was not statistically significant. Glioma patients had higher CPC levels compared to patients with meningiomas. Larger studies are obviously needed to verify the role of CPC levels in patients with brain tumors.
- Subjects :
- Adult
Male
Oncology
Pathology
medicine.medical_specialty
Angiogenesis
CD34
Brain tumor
Disease-Free Survival
Neovascularization
Meningioma
Internal medicine
Glioma
Meningeal Neoplasms
medicine
Humans
Prospective Studies
Progenitor cell
Prospective cohort study
Aged
Neovascularization, Pathologic
Brain Neoplasms
business.industry
General Medicine
Middle Aged
Hematopoietic Stem Cells
medicine.disease
Magnetic Resonance Imaging
nervous system diseases
Female
Neurology (clinical)
medicine.symptom
Glioblastoma
business
Subjects
Details
- ISSN :
- 22402993 and 03009009
- Volume :
- 113
- Database :
- OpenAIRE
- Journal :
- Acta Neurologica Belgica
- Accession number :
- edsair.doi.dedup.....a71117e7f3ad85539d854ec958eb9beb