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Obstructed defecation-an enteric neuropathy? An exploratory study of patient samples
- Source :
- International journal of colorectal disease. 34(1)
- Publication Year :
- 2018
-
Abstract
- Although various strategies exist for chronic constipation therapy, the pathogenesis of chronic constipation is still not completely understood. The aim of this exploratory experimental study is to elucidate alterations of the autonomous enteric nervous system at the molecular level in patients with obstructed defecation, who represent one of the most predominant groups of constipated patients. Full-thickness rectal wall samples of patients with obstructed defecation were analyzed and compared with controls. Differential gene expression analyses by RNA-Seq transcriptome profiling were performed and gene expression profiles were assigned to gene ontology pathways by application of different biological libraries. Analysis of the transcriptome showed that genes associated with the enteric nervous system functions were significantly downregulated in patients with obstructed defecation. These affected functions included developmental processes and synaptic transmission. Our results therefore indicate that obstructed defecation may represent an enteric neuropathy, comparable to Hirschsprung disease and slow-transit constipation.
- Subjects :
- medicine.medical_specialty
Constipation
Gastroenterology
Transcriptome
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Defecation
Chronic constipation
Enteric neuropathy
business.industry
Gene Expression Profiling
Intestinal Pseudo-Obstruction
Hepatology
Middle Aged
medicine.disease
Databases as Topic
Gene Expression Regulation
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Enteric nervous system
Female
Obstructed defecation
medicine.symptom
business
Subjects
Details
- ISSN :
- 14321262
- Volume :
- 34
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- International journal of colorectal disease
- Accession number :
- edsair.doi.dedup.....a7105087f10f600ad4b1dd59f6a9f555