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Parathyroid Carcinoma and Ectopic Secretion of Parathyroid hormone
- Source :
- Endocrinology and Metabolism Clinics of North America. 50:683-709
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- The most common causes of hypercalcemia are primary hyperparathyroidism (PHPT) and malignancy. Parathyroid carcinoma (PC), causing a severe PHPT, is the rarest parathyroid tumor. A diagnosis of PC is challenging because the clinical profile overlaps with that of benign counterpart. Surgery is the mainstay treatment. CDC73 mutations have been detected in up to 80% of sporadic PCs. Ectopic production of parathyroid hormone (PTH) by malignant nonparathyroid tumors is a rare condition accounting for less than 1% of hypercalcemia of malignancy. PTH secretion can be considered an aberration in the tissue specificity of gene expression and may involve heterogeneous molecular mechanisms.
- Subjects :
- CDC73
HPT-JT
Hypercalcemia
Parafibromin
PI3K/AKT/mTOR
Primary hyperparathyroidism
PTH
endocrine system diseases
Endocrinology, Diabetes and Metabolism
Parathyroid hormone
Malignancy
Endocrinology
Gene expression
medicine
Humans
Secretion
business.industry
medicine.disease
Tissue specificity
Parathyroid Neoplasms
Parathyroid carcinoma
Parathyroid Hormone
Cancer research
business
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 08898529
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Endocrinology and Metabolism Clinics of North America
- Accession number :
- edsair.doi.dedup.....a70f9631cb4e8504cd11efaa64edd2c1