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Differences in serum bile acid composition between unoperated cirrhotic patients and patients with portacaval or mesocaval shunt
- Source :
- Scopus-Elsevier
-
Abstract
- Serum bile acids were determined in 13 cirrhotic patients with portacaval shunt and in 15 with mesocaval shunt. 20 nonshunted cirrhotics were used as controls. Serum bile acid levels were higher in portacaval (26.7 +/- 14.3 micrograms/ml) than in mesocaval shunt patients (16.9 +/- 8.1 micrograms/ml) and controls (14.1 +/- 11.5 micrograms/ml). The cholic/chenodeoxycholic ratio was lower after portacaval shunt than after mesocaval shunt (0.36 +/- 0.15 and 0.63 +/- 0.26, respectively). It is hypothesized that these findings may be consistent with a larger hepatic blood flow present in mesocaval shunted patients and with chenodeoxycholic absorption in the upper small intestine.
- Subjects :
- Liver Cirrhosis
Adult
Male
medicine.medical_specialty
medicine.drug_class
Liver Circulation
Humans
Methods
Aged
Portacaval Shunt, Surgical
Cholic Acids
Bile Acids and Salts
Chenodeoxycholic Acid
Middle Aged
Female
Portacaval
Portacaval shunt
Gastroenterology
chemistry.chemical_compound
Portacaval Shunt
Chenodeoxycholic acid
Internal medicine
Surgical
medicine
Settore MED/12 - Gastroenterologia
Bile acid
business.industry
Portacaval anastomosis
Cholic acid
Blood flow
Small intestine
medicine.anatomical_structure
chemistry
business
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....a70e3d556790cd1c8245e3810905309b