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Triterpene saponins from the roots of Dipsacus asper and their protective effects against the Aβ25–35 induced cytotoxicity in PC12 cells
- Source :
- Fitoterapia. 83:843-848
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Three new triterpene saponins, named asperosaponin A–C (1–3), together with seven known triterpene saponins (4–10) were isolated from the roots of Dipsacus asper. The structures of compounds 1–3 were elucidated on the basis of detailed spectroscopic analysis and chemical methods. Compounds 1–3, 6–10 had significantly protective effects in PC12 cells against the Aβ25-35 induced cytotoxicity. All the compounds isolated showed no cytotoxic activity against three human cancer cell lines, A-549, Bel-7402 and BGC-823.
- Subjects :
- Amyloid β
Stereochemistry
Dipsacus asper
Adrenal Gland Neoplasms
Pheochromocytoma
PC12 Cells
Plant Roots
Triterpene
Drug Discovery
Animals
Humans
Cytotoxic T cell
Cytotoxicity
Pharmacology
chemistry.chemical_classification
Amyloid beta-Peptides
Molecular Structure
Plant Extracts
Chemistry
Dipsacaceae
General Medicine
Saponins
Antineoplastic Agents, Phytogenic
Peptide Fragments
Rats
Biochemistry
Cell culture
Human cancer
Phytotherapy
Subjects
Details
- ISSN :
- 0367326X
- Volume :
- 83
- Database :
- OpenAIRE
- Journal :
- Fitoterapia
- Accession number :
- edsair.doi.dedup.....a70d88be8d62e359b9af023751695e89