Back to Search
Start Over
Sleep and the gut microbiome in psoriasis: clinical implications for disease progression and the development of cardiometabolic comorbidities
- Source :
- J Psoriasis Psoriatic Arthritis, Journal of psoriasis and psoriatic arthritis, vol 6, iss 1
- Publication Year :
- 2020
-
Abstract
- Background: Sleep dysfunction and sleep disorders are important comorbidities of psoriasis. Not only do these sleep comorbidities contribute to reduced quality of life, but they may also lead to worsening psoriasis and increased susceptibility to cardiometabolic diseases. While psoriasis and sleep dysfunction are thought to be linked by itch, depression, and immune system dysregulation, the relationship between psoriasis and sleep dysfunction is not yet fully understood. Objective: We sought to compare previous studies characterizing the gut microbiome in psoriasis and sleep dysfunction and examine the potential relevance of shared findings on cardiometabolic and overall health. Methods: We performed literature searches of PubMed and Embase databases to find studies evaluating the gut microbiome in psoriasis, sleep dysfunction, and cardiometabolic diseases. Results: Studies characterizing the gut microbiome in psoriasis and sleep dysfunction reveal shared findings, specifically an increased Firmicutes to Bacteroidetes ratio and reduced abundance of short-chain fatty acid–producing bacteria. These dysbiotic features have also been shown to promote systemic inflammation and cardiometabolic disease. Conclusion: In favoring an increased Firmicutes to Bacteroidetes ratio and reduced abundance of short-chain fatty acid–producing bacteria, sleep dysfunction could be contributing to worsening psoriasis and cardiometabolic comorbidities through intestinal dysbiosis. Future studies are needed to determine whether gut- and sleep-targeting interventions could be therapeutic in patients with psoriasis having poor sleep.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
insomnia
microbiome
Dermatology
Autoimmune Disease
Article
03 medical and health sciences
flora
0302 clinical medicine
Rheumatology
Clinical Research
Psoriasis
Internal medicine
Complementary and Integrative Health
Insomnia
microbiota
Medicine
2.1 Biological and endogenous factors
Microbiome
Aetiology
obstructive sleep apnea
sleep dysfunction
sleep disorder
Sleep disorder
business.industry
dysbiosis
psoriasis
medicine.disease
Sleep in non-human animals
sleep deprivation
Obstructive sleep apnea
Sleep deprivation
030104 developmental biology
Good Health and Well Being
medicine.symptom
business
Sleep Research
Digestive Diseases
Dysbiosis
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- J Psoriasis Psoriatic Arthritis, Journal of psoriasis and psoriatic arthritis, vol 6, iss 1
- Accession number :
- edsair.doi.dedup.....a7048b5c749038492dca74fa7714a375