Back to Search
Start Over
Association Between Sudden Sensorineural Hearing Loss and History of Statin Use: A Nested Case‐Control Study
- Source :
- Otolaryngology–Head and Neck Surgery. 165:149-156
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- The effect of statin on sudden sensorineural hearing loss (SSNHL) remains unclear. Thus, this study aimed to investigate the association between prior statin use and SSNHL.A nested case-control study.Participants aged ≥40 years were enrolled from the 2002-2015 Korean National Health Insurance Service-Health Screening Cohort.A total of 5876 patients with SSNHL were matched with 23,504 control participants for age, sex, income, and region of residence. History of statin use for 2 years before SSNHL onset was investigated between the groups. The odds ratios (ORs) of the length of statin use for SSNHL stratified by age, sex, income, and region of residence were analyzed with conditional logistic regression. Dyslipidemia, total cholesterol, blood pressure, blood glucose, hemoglobin, obesity, smoking, alcohol consumption, and Charlson Comorbidity Index score were adjusted. The adjusted variables were subjected to subgroup analyses.The SSNHL group had a longer duration of statin use than the control group (mean [SD], 81.9 [197.7] days vs 72.7 [188.0] days;Previous statin use was not associated with SSNHL.
- Subjects :
- Adult
Male
medicine.medical_specialty
Statin
medicine.drug_class
Hearing loss
Hearing Loss, Sensorineural
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Republic of Korea
Odds Ratio
Humans
Medicine
030223 otorhinolaryngology
Aged
Aged, 80 and over
business.industry
Age Factors
Case-control study
Hearing Loss, Sudden
Middle Aged
Statin treatment
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Logistic Models
Otorhinolaryngology
Case-Control Studies
Sudden sensorineural hearing loss
Nested case-control study
Female
Surgery
medicine.symptom
business
030217 neurology & neurosurgery
Cohort study
Subjects
Details
- ISSN :
- 10976817 and 01945998
- Volume :
- 165
- Database :
- OpenAIRE
- Journal :
- Otolaryngology–Head and Neck Surgery
- Accession number :
- edsair.doi.dedup.....a7003088e02a98020a9132829ee4bbbe