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Expression of the Epstein-Barr virus latent membrane protein in nasopharyngeal carcinoma biopsy specimens
- Source :
- Human Pathology. 24:239-242
- Publication Year :
- 1993
- Publisher :
- Elsevier BV, 1993.
-
Abstract
- It has been known for some time that the Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC). The tumor cells are known to harbor EBV in a latent state. Latently-infected B cells that have become growth transformed by EBV in vitro express some 10 antigens, two of which (Epstein-Barr nuclear antigen 2 [EBNA2] and the latent membrane protein [LMP]) are associated with cellular transformation. We evaluated the expression of these two EBV antigens in NPC by probing tissue sections with monoclonal antibodies. We found that EBNA2 was not expressed and that LMP was expressed in seven of nine biopsy specimens. It is therefore postulated that either there are subsets of NPC or that LMP may be involved only in certain stages of tumor formation.
- Subjects :
- China
Herpesvirus 4, Human
medicine.drug_class
Biopsy
viruses
Fluorescent Antibody Technique
Biology
medicine.disease_cause
Monoclonal antibody
Virus
Herpesviridae
Pathology and Forensic Medicine
Viral Matrix Proteins
Antigen
hemic and lymphatic diseases
otorhinolaryngologic diseases
medicine
Humans
Gammaherpesvirinae
Antigens, Viral
medicine.diagnostic_test
Antibodies, Monoclonal
Nasopharyngeal Neoplasms
medicine.disease
biology.organism_classification
Epstein–Barr virus
Virology
DNA-Binding Proteins
Gene Expression Regulation, Neoplastic
stomatognathic diseases
Cell Transformation, Neoplastic
Epstein-Barr Virus Nuclear Antigens
Nasopharyngeal carcinoma
Cancer research
Subjects
Details
- ISSN :
- 00468177
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Human Pathology
- Accession number :
- edsair.doi.dedup.....a6fa6a32466c2755f2a5df142c2c04f7