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Spinal muscular atrophy with progressive myoclonic epilepsy linked to mutations in ASAH1

Authors :
Gonca Bektaş
Nur Aydınlı
Meral Özmen
Edibe Pembegül Yıldız
Burak Tatlı
Gozde Yesil
Mine Çalışkan
Source :
Clinical Neurology and Neurosurgery. 164:47-49
Publication Year :
2018
Publisher :
Elsevier BV, 2018.

Abstract

Spinal muscular atrophy with progressive myoclonic epilepsy (SMA-PME), a rare disorder caused by mutation in the ASAH1 gene, is characterized by progressive muscle weakness and intractable epilepsy. The literature about SMA-PME is very rare and most of the time limited to case reports. Mutation in the ASAH1 gene is also found in another rare syndrome which is Farber disease. We report a case of a 13.5-year-old girl with SMA-PME associated with ASAH1 gene mutation. She presented with progressive muscle weakness, tremor, seizure, and cognitive impairment. Clinical features and electrophysiological investigations revealed a motor neuron disease and generalized epilepsy. The marked difference in disease manifestations may explain why Farber and SMA-PME diseases were not suspected of being allelic conditions. SMA-PME cases with ASAH1 mutation could be treated using therapeutic studies regarding Farber disease. In patients with undefined PME or lower motor neuron disease cases, ASAH1 mutation scans should be studied.

Details

ISSN :
03038467
Volume :
164
Database :
OpenAIRE
Journal :
Clinical Neurology and Neurosurgery
Accession number :
edsair.doi.dedup.....a6f8baf4bb7fd0c54e8e74d7bd398639