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Learning about Kawasaki disease from COVID-19 and the Multisystem Inflammatory Syndrome in Children
- Source :
- Current Opinion in Pediatrics
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- Purpose of review Multisystem Inflammatory Syndrome in Children (MIS-C) is a novel syndrome that has appeared in the wake of the severe acute respiratory syndrome coronavirus -2 pandemic, with features that overlap with Kawasaki disease (KD). As a result, new interest and focus have arisen in KD, and specifically mechanisms of the disease. Recent findings A major question in the literature on the nature of MIS-C is if, and how, it may be related to KD. This has been explored using component analysis type studies, as well as other unsupervised analysis, as well as direct comparisons. At present, the answer to this question remains opaque, and several studies have interpreted their findings in opposing ways. Studies seem to suggest some relationship, but that MIS-C and KD are not the same syndrome. Summary Study of MIS-C strengthens the likelihood that KD is a postinfectious immune response, and that perhaps multiple infectious agents or viruses underlie the disease. MIS-C and KD, while not the same disease, could plausibly be sibling disorders that fall under a larger syndrome of postacute autoimmune febrile responses to infection, along with Kawasaki shock syndrome.
- Subjects :
- 2019-20 coronavirus outbreak
Kawasaki disease
Coronavirus disease 2019 (COVID-19)
SARS-CoV-2
business.industry
COVID-19
Disease
Mucocutaneous Lymph Node Syndrome
medicine.disease
Multisystem Inflammatory Syndrome in Children
Systemic Inflammatory Response Syndrome
toxic shock syndrome
Immune system
Pediatrics, Perinatology and Child Health
Pandemic
Immunology
medicine
Humans
ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Jordan S. Orange
Severe acute respiratory syndrome coronavirus
Sibling
Child
business
Subjects
Details
- ISSN :
- 1531698X and 10408703
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Pediatrics
- Accession number :
- edsair.doi.dedup.....a6eebe410eb0890e075657b24778c1a8