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Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase
- Source :
- Angewandte Chemie International Edition. 55:4247-4251
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Acetohydroxyacid synthase (AHAS) inhibitors are highly successful commercial herbicides. New kinetic data show that the binding of these compounds leads to reversible accumulative inhibition of AHAS. Crystallographic data (to a resolution of 2.17 Å) for an AHAS-herbicide complex shows that closure of the active site occurs when the herbicidal inhibitor binds, thus preventing exchange with solvent. This feature combined with new kinetic data shows that molecular oxygen promotes an accumulative inhibition leading to the conclusion that the exceptional potency of these herbicides is augmented by subversion of an inherent oxygenase side reaction. The reactive oxygen species produced by this reaction are trapped in the active site, triggering oxidation reactions that ultimately lead to the alteration of the redox state of the cofactor flavin adenine dinucleotide (FAD), a feature that accounts for the observed reversible accumulative inhibition.
- Subjects :
- 0301 basic medicine
Oxygenase
Side reaction
Nanotechnology
Oxidative phosphorylation
010402 general chemistry
01 natural sciences
Redox
Catalysis
Cofactor
03 medical and health sciences
chemistry.chemical_compound
chemistry.chemical_classification
Flavin adenine dinucleotide
Reactive oxygen species
biology
Herbicides
010405 organic chemistry
Active site
General Medicine
General Chemistry
0104 chemical sciences
Acetolactate Synthase
030104 developmental biology
chemistry
Biophysics
biology.protein
Oxidation-Reduction
Subjects
Details
- ISSN :
- 15213773 and 14337851
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie International Edition
- Accession number :
- edsair.doi.dedup.....a6e2a2871e2100700eb013e5914c8292