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Gene expression analysis provides a potential rationale for revising the histological grading of follicular lymphomas
- Publication Year :
- 2008
-
Abstract
- Background Follicular lymphomas are currently subdivided into grades I, II, IIIa and IIIb. This distinction is, however, questioned.Design and Methods We studied the gene expression profile of 43 follicular lymphomas, 50 B-cell non-Hodgkin’s lymphomas of different histotype, and 20 samples of normal B-lymphocytes in order to assess: (i) the relationship of follicular lymphoma with normal B cells and other B-cell non-Hodgkin’s lymphomas; (ii) whether follicular lymphoma is a unique disease; and (iii) whether follicular lymphoma grade IIIb is closer to follicular lymphoma or diffuse large B-cell lymphoma of the germinal center B-cell type.Results First, we found that the molecular profile of follicular lymphoma is intimately related to that of normal germinal center B cells, irrespectively of the histological grade. Secondly, we observed that follicular lymphoma has a relatively homogeneous gene expresion profile that is distinct from that of other B-cell non-Hodgkin’s lymphoma and does not include discrete molecular subgroups. However, by further clustering samples according to signatures differentially expressed among follicular lymphomas or in follicular lymphomas versus diffuse large B-cell lymphoma, we showed that grade I–IIIa tumors tend to cluster together, while grade IIIb follicular lymphoma constitutes a distinct subgroup, whose molecular signature is closer to that of the remaining follicular lymphomas than to that of diffuse large B-cell lymphoma of the germinal center B-cell type.Conclusions These data support the hypothesis that grade IIIb follicular lymphoma does indeed belong to the group of follicular lymphomas rather than diffuse large B-cell lymphomas, and also suggests a possible revision of the histological grading of follicular lymphomas, with their simple distinction into follicular lymphoma (grade I–IIIa) and follicular lymphoma/large cell (grade IIIb).
- Subjects :
- Adult
Male
endocrine system
medicine.medical_specialty
Pathology
Lymphoma, B-Cell
Follicular lymphoma
Biology
immune system diseases
hemic and lymphatic diseases
Internal medicine
Follicular phase
medicine
Cluster Analysis
Humans
Grading (tumors)
Lymphoma, Follicular
Aged
Neoplasm Staging
Oligonucleotide Array Sequence Analysis
Hematology
Genome, Human
Large cell
Gene Expression Profiling
Lymphoma, Non-Hodgkin
Germinal center
Middle Aged
medicine.disease
Non-Hodgkin's lymphoma
Lymphoma
Gene Expression Regulation, Neoplastic
Female
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....a6e0116df7031f54571cfb4c83422739