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Health-related Quality of Life in Adolescent Patients With Hepatitis C Genotype 1 Treated With Sofosbuvir and Ledipasvir
- Source :
- Journal of pediatric gastroenterology and nutrition. 66(1)
- Publication Year :
- 2017
-
Abstract
- The aim of the study was to assess the effect of treatment with ledipasvir/sofosbuvir (LDV/SOF) on the health-related quality of life (HRQL) of pediatric patients with chronic hepatitis C virus (HCV) infection.Adolescents (12-17 years) with HCV were treated with LDV/SOF (90/400 mg daily) for 12 weeks. HRQL was assessed using the PedsQLv4.0-SF15 completed by the children and caregivers before, during, and after treatment.We included 100 adolescents with HCV genotype 1 infection (14.7 ± 2.0 years, 1% known cirrhosis, 80% treatment-naïve, 97% sustained virologic response-12). At baseline, HRQL the caregiver- perceived HRQL scores were lower than adolescents' self-reported scores (by 6.7-7.9 points, all P 0.01). At the end of 12 weeks of treatment, however, the caregiver-reported HRQL scores showed a significant improvement (+all P 0.04), whereas the adolescents' self-reported scores did not change from the baseline. HRQL scores reported by caregivers remained higher than baseline (by +4.7-+7.5, P 0.01) through 12 weeks after treatment, as did the adolescents' self-reported Emotional Functioning scores (+4.3 from baseline, P = 0.0009); observed improvements were sustained after 24 weeks of follow-up (all P 0.04). Multivariate analysis showed that, after adjustment for location, age, and sex, having a history of anxiety and panic disorders were consistent predictors of impaired HRQL in adolescents with HCV infection (P 0.05).Treatment of HCV in adolescents with LDV/SOF is associated with some improvement in HRQL. Caregivers' reports of HRQL in adolescents with HCV significantly increased with treatment and were similar to the adolescent self-reported HRQL after sustained virologic response-12.
- Subjects :
- Ledipasvir
Male
medicine.medical_specialty
Sofosbuvir
Adolescent
Antiviral Agents
Virus
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Quality of life
Internal medicine
Medicine
Health Status Indicators
Humans
030212 general & internal medicine
Prospective Studies
Prospective cohort study
Child
Fluorenes
business.industry
Ribavirin
Gastroenterology
Hepatitis C
Hepatitis C, Chronic
medicine.disease
Clinical trial
Treatment Outcome
chemistry
Caregivers
Pediatrics, Perinatology and Child Health
Quality of Life
030211 gastroenterology & hepatology
Benzimidazoles
Female
Self Report
business
Uridine Monophosphate
medicine.drug
Follow-Up Studies
Subjects
Details
- ISSN :
- 15364801
- Volume :
- 66
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of pediatric gastroenterology and nutrition
- Accession number :
- edsair.doi.dedup.....a6d6ea54aef7572e8dbcdd28b60a1e9f