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Engineering nanotheranostic strategies for liver cancer
- Source :
- World Journal of Gastrointestinal Oncology
- Publication Year :
- 2021
- Publisher :
- Baishideng Publishing Group Inc., 2021.
-
Abstract
- The incidence and mortality of hepatocellular carcinoma have continued to increase over the last few years, and the medicine-based outlook of patients is poor. Given great ideas from the development of nanotechnology in medicine, especially the advantages in the treatments of liver cancer. Some engineering nanoparticles with active targeting, ligand modification, and passive targeting capacity achieve efficient drug delivery to tumor cells. In addition, the behavior of drug release is also applied to the drug loading nanosystem based on the tumor microenvironment. Considering clinical use of local treatment of liver cancer, in situ drug delivery of nanogels is also fully studied in orthotopic chemotherapy, radiotherapy, and ablation therapy. Furthermore, novel therapies including gene therapy, phototherapy, and immunotherapy are also applied as combined therapy for liver cancer. Engineering nonviral polymers to function as gene delivery vectors with increased efficiency and specificity, and strategies of co-delivery of therapeutic genes and drugs show great therapeutic effect against liver tumors, including drug-resistant tumors. Phototherapy is also applied in surgical procedures, chemotherapy, and immunotherapy. Combination strategies significantly enhance therapeutic effects and decrease side effects. Overall, the application of nanotechnology could bring a revolutionary change to the current treatment of liver cancer.
- Subjects :
- Poor prognosis
Oncology
Drug
medicine.medical_specialty
Combination therapy
medicine.medical_treatment
media_common.quotation_subject
Gene delivery
Frontier
Internal medicine
medicine
media_common
business.industry
Gastroenterology
Immunotherapy
medicine.disease
Radiation therapy
Hepatocellular carcinoma
Drug delivery
Nanotheranostic
Liver cancer
business
Subjects
Details
- ISSN :
- 19485204
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- World Journal of Gastrointestinal Oncology
- Accession number :
- edsair.doi.dedup.....a6d499fbc5cfa5767f76f06ecfc5f273