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Pregnancy in Catecholaminergic Polymorphic Ventricular Tachycardia
- Source :
- JACC: Clinical Electrophysiology, 5(3), 387-394. Elsevier USA
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Objectives This investigation was a retrospective study of catecholaminergic polymorphic ventricular tachycardia (CPVT) patients in Canada and the Netherlands to compare pregnancy, postpartum, and nonpregnant event rates. Background CPVT is characterized by life-threatening arrhythmias during exertion or emotional stress. The arrhythmic risk in CPVT patients during pregnancy is unknown. Methods Baseline demographics, genetics, treatment, and pregnancy complications were reviewed. Event rate calculations assumed a 40-week pregnancy and 24-week postpartum period. Results Ninety-six CPVT patients had 228 pregnancies (median 2 pregnancies per patient; range: 1 to 10; total: 175.4 pregnant patient-years). The median age of CPVT diagnosis was 40.7 years (range: 12 to 84 years), with a median follow-up of 2.9 years (range: 0 to 20 years; total 448.1 patient-years). Most patients had pregnancies before CPVT diagnosis (82%). Pregnancy and postpartum cardiac events included syncope (5%) and an aborted cardiac arrest (1%), which occurred in patients who were not taking beta-blockers. Other complications included miscarriages (13%) and intrauterine growth restriction (1 case). There were 6 cardiac events (6%) during the nonpregnant period. The pregnancy and postpartum event rates were 1.71 and 2.85 events per 100 patient-years, respectively, and the combined event rate during the pregnancy and postpartum period was 2.14 events per 100 patient-years. These rates were not different from the nonpregnant event rate (1.46 events per 100 patient-years). Conclusions The combined pregnancy and postpartum arrhythmic risk in CPVT patients was not elevated compared with the nonpregnant period. Most patients had pregnancies before diagnosis, and all patients with events were not taking beta-blockers at the time of the event.
- Subjects :
- Adult
medicine.medical_specialty
Pregnancy Complications, Cardiovascular
sudden death
Intrauterine growth restriction
cardiac arrest
030204 cardiovascular system & hematology
arrhythmia
Catecholaminergic polymorphic ventricular tachycardia
Sudden death
Young Adult
03 medical and health sciences
0302 clinical medicine
Humans
Medicine
In patient
030212 general & internal medicine
Exertion
Retrospective Studies
Pregnancy
catecholaminergic polymorphic ventricular tachycardia
business.industry
Obstetrics
Postpartum Period
Pregnancy Outcome
Retrospective cohort study
medicine.disease
syncope
Tachycardia, Ventricular
Female
pregnancy
business
Postpartum period
Subjects
Details
- ISSN :
- 2405500X
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- JACC: Clinical Electrophysiology
- Accession number :
- edsair.doi.dedup.....a6ce4d3eecd9ea81722be819e15fe46c