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Anxiolytic effects of dopamine receptor ligands: I. involvement of dopamine autoreceptors
- Source :
- Life Sciences. 62:649-663
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- The anxiolytic-like properties of dopamine agonists and antagonists with different receptor profiles were investigated in the ultrasonic vocalization test in rats after subcutaneous administration. Only dopamine D2 receptor agonists inhibited ultrasonic vocalization with the following ED50 values: apomorphine (0.07 mg kg ), quinelorane (0.01 mg kg ), quinpirole (0.04 mg kg ), pramipexole (0.09 mg kg ), roxindole (0.04 mg kg ), talipexole (0.04 mg kg ), (±)-7-OH-DPAT (0.05 mg kg ), (±)-PPHT (0.03 mg kg ), (−)-TNPA (0.06 mg kg ), PD128907 (0.13 mg kg ). The D2 antagonists haloperidol, mazapertine, raclopride, remoxipride, L745870, U99194A, U101958 and S(−)-DS121, the partial agonists PD143188 and preclamol, the selective D1 agonist R(+)-SKF38393 and the D1 antagonist SCH23390, and the uptake inhibitors GBR12909, GBR12935 and indatraline lacked significant inhibitory effects on ultrasonic vocalization. Because at least some of the D2 receptor agonists investigated have selectivity for dopamine autoreceptors, it is speculated that the dopamine autoreceptor may be a target for the development of new antianxiety drugs.
- Subjects :
- Male
Agonist
Quinelorane
medicine.drug_class
Pharmacology
Ligands
General Biochemistry, Genetics and Molecular Biology
Rats, Sprague-Dawley
chemistry.chemical_compound
Dopamine Uptake Inhibitors
Roxindole
Dopamine receptor D2
medicine
Animals
Neurotransmitter Uptake Inhibitors
General Pharmacology, Toxicology and Pharmaceutics
Autoreceptors
7-OH-DPAT
Raclopride
Diazepam
Receptors, Dopamine D2
General Medicine
Talipexole
Rats
Anti-Anxiety Agents
chemistry
Dopamine receptor
Dopamine Agonists
Dopamine Antagonists
Vocalization, Animal
medicine.drug
Subjects
Details
- ISSN :
- 00243205
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Life Sciences
- Accession number :
- edsair.doi.dedup.....a6c24ce949e829d7fa441ed4a438c09c