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Anti-formyl peptide antibodies
- Source :
- Bioorganic & Medicinal Chemistry Letters. 17:1943-1945
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- Antibodies that selectively bind to N-formylmethionyl leucyl phenylalanine (fMLF, also known as fMLP) have been generated. These antibodies bound to fMLF with higher affinity than to non-formylated peptide MLF: the differences in the binding energies between fMLF and MLF were 1.4->2.1 kcal/mol.
- Subjects :
- Stereochemistry
Chemistry, Pharmaceutical
Clinical Biochemistry
Molecular Conformation
Serum albumin
Pharmaceutical Science
Peptide
Phenylalanine
Plasma protein binding
Tripeptide
Biochemistry
Antibodies
Drug Discovery
Animals
Humans
Receptor
Molecular Biology
chemistry.chemical_classification
biology
Organic Chemistry
Serum Albumin, Bovine
hemic and immune systems
Biological activity
Receptors, Formyl Peptide
N-Formylmethionine Leucyl-Phenylalanine
Kinetics
Models, Chemical
chemistry
Drug Design
Immunoglobulin G
biology.protein
Molecular Medicine
Cattle
Antibody
Peptides
Protein Binding
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....a6bf02b3a85a7aa88b7b42fcfbfcee1a
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.01.082