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Haemodialysis Efficiency After Long-Term Treatment with Recombinant Human Erythropoietin
- Source :
- Nephrology Dialysis Transplantation. 4:718-720
- Publication Year :
- 1989
- Publisher :
- Oxford University Press (OUP), 1989.
-
Abstract
- In 11 chronic haemodialysis patients we investigated whether the increase in haematocrit during recombinant human erythropoietin (rHuEPO) treatment might alter the long-term efficiency of haemodialysis. After correction of anaemia with rHuEPO (mean Ht 35 +/- 2% vs 19 +/- 2% at baseline) (p 0.001), mean predialysis creatinine and urea did not change, while predialysis phosphate (1.77 +/- 0.38 vs 1.51 +/- 0.29 mmol/l) were significantly increased (p 0.01). In six of the 11 rHuEPO treated patients a post- versus pre-dialysis haemoconcentration (haematocrit 44% vs 35%) not attributable to different ultrafiltration regimes, was observed. In these 6 patients mean predialysis phosphate, creatinine and urea tended to be higher, but not significantly, in comparison to he remaining 5 patients who did not haemoconcentrate. Dialyser clearances and total extractions for urea, creatinine, phosphate and inulin were compared to those of 11 matched haemodialysis patients with anaemia. No differences were observed either for small and middle molecule clearances or their extractions between rHuEPO and anaemic patients. In conclusion, dialysis efficiency is not affected if haematocrit values are kept about 35%.
- Subjects :
- Adult
Male
medicine.medical_specialty
Resuscitation
Anemia
medicine.medical_treatment
Urology
Efficiency
Hematocrit
Drug Administration Schedule
Phosphates
chemistry.chemical_compound
Renal Dialysis
Internal medicine
medicine
Humans
Urea
Erythropoietin
Dialysis
Transplantation
Creatinine
medicine.diagnostic_test
business.industry
Middle Aged
Reference Standards
medicine.disease
Recombinant Proteins
Endocrinology
chemistry
Nephrology
Female
Hemodialysis
business
medicine.drug
Subjects
Details
- ISSN :
- 14602385 and 09310509
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Nephrology Dialysis Transplantation
- Accession number :
- edsair.doi.dedup.....a6b7b1028474dc76b4b30cd18170f54f