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Heterogeneous distribution of conjugation activities of harmol in isolated rat liver cells
- Source :
- Journal of pharmacobio-dynamics. 7(9)
- Publication Year :
- 1984
-
Abstract
- The regional distribution of the conjugation reaction activities of harmol was examined in isolated rat liver cells fractionated to the centrilobular and periportal regions. The heterogeneous distribution in the conjugation rates per unit cell numbers was found only in glucuronidation. The difference in the metabolic intrinsic clearance per total cell numbers in each region was mainly due to the cell numbers, resulting that the metabolic abilities in both reactions are higher in the periportal region than the centrilobular region. This finding in sulfate conjugation is consistent with the results in the isolated perfused liver previously presented by other investigators but the result that in glucuronide conjugation is contradictory to them.
- Subjects :
- Male
Glucuronidation
Glucuronates
Cell Separation
In Vitro Techniques
Cell Fractionation
5'-nucleotidase
chemistry.chemical_compound
Alkaloids
Cytochrome P-450 Enzyme System
Nucleotidases
medicine
Animals
5'-Nucleotidase
Pharmacology
Harmol
biology
Portal Vein
Sulfates
Alcohol Dehydrogenase
Cytochrome P450
Rats, Inbred Strains
Metabolism
Rats
Perfusion
Alcohol Oxidoreductases
Harmine
Kinetics
medicine.anatomical_structure
chemistry
Biochemistry
Liver
Hepatocyte
biology.protein
Cell fractionation
Glucuronide
Subjects
Details
- ISSN :
- 0386846X
- Volume :
- 7
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of pharmacobio-dynamics
- Accession number :
- edsair.doi.dedup.....a6b00b2a19990388139fe6aaf54a4179