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Involvement of the primate specific gene G72 in schizophrenia: From genetic studies to pathomechanisms
- Source :
- Neuroscience and biobehavioral reviews. 37(10 Pt 1)
- Publication Year :
- 2012
-
Abstract
- Schizophrenia is a human mental disorder that affects an individual's thoughts, perception, affect and behavior, which is caused by a complex interaction of genetic and environmental factors. Genetic studies have implicated the evolutionary novel, anthropoid primate-specific gene locus G72/G30 in the etiology of schizophrenia and other psychiatric disorders. This gene encodes the protein LG72, which has been discussed as a modulator of the peroxisomal enzyme d-amino-acid-oxidase (DAO), or, alternatively as a mitochondrial protein. Recently, G72 transgenic (G72Tg) mice were generated that express the protein throughout the brain. These mice show several behavioral deficits that are related to schizophrenia. Further, G72Tg mice have a reduced activity of mitochondrial complex I, with a concomitantly increased production of reactive oxygen species, as well as deficits in short-term plasticity. Results from these studies demonstrate that expression of the human G72/G30 gene locus in mice produces behavioral phenotypes that are relevant to schizophrenia. They implicate LG72-induced mitochondrial and synaptic defects as a possible pathomechanism of this disease.
- Subjects :
- Mitochondrial Diseases
Cognitive Neuroscience
Transgene
Mice, Transgenic
Disease
Biology
medicine.disease_cause
Behavioral Neuroscience
Mice
medicine
Animals
Humans
Mitochondrial protein
Gene
Genetics
chemistry.chemical_classification
Reactive oxygen species
Electron Transport Complex I
Neuronal Plasticity
Behavior, Animal
Intracellular Signaling Peptides and Proteins
Brain
medicine.disease
Primate specific
Neuropsychology and Physiological Psychology
chemistry
Schizophrenia
Carrier Proteins
Oxidative stress
Subjects
Details
- ISSN :
- 18737528
- Volume :
- 37
- Issue :
- 10 Pt 1
- Database :
- OpenAIRE
- Journal :
- Neuroscience and biobehavioral reviews
- Accession number :
- edsair.doi.dedup.....a6a19a921a64c66e5bca0687810326df