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B-type natriuretic peptide as a marker of heart failure: new insights from biochemistry and clinical implications
- Source :
- Biomarkers in medicine. 4(2)
- Publication Year :
- 2010
-
Abstract
- The mature, biologically active 32-amino acid long B-type natriuretic peptide (BNP1–32), is cleaved by corin from the BNP prohormone. Recent data demonstrated that BNP1–32 might be an ideal substrate for the endogenous aminopeptidase, dipeptidyl-peptidase (DPP) IV. DPP IV removes the two amino-terminal amino acids (Ser and Pro) from BNP1–32 to produce BNP3–32, which has been detected in plasma of patients with heart failure. In a canine model, intravenous BNP3–32 infusion resulted in less natriuresis, diuresis and vasodilation compared to intravenous infusion of BNP1–32. The clinical relevance of these observations may be important for patients with high plasma BNP concentrations, which can be measured by commercially available immunoassays. Further studies are needed to explore whether DPP IV inhibitors increase the bioavailability of BNP1–32, delay the progression of heart failure and increase the efficacy of exogenously administered BNP1–32 in decompensated heart failure.
- Subjects :
- medicine.medical_specialty
Natriuretic Agents
medicine.drug_class
Clinical Biochemistry
Prohormone
Diuresis
Vasodilation
Natriuresis
Internal medicine
Drug Discovery
Natriuretic Peptide, Brain
Natriuretic peptide
medicine
Animals
Humans
cardiovascular diseases
Heart Failure
business.industry
Biochemistry (medical)
medicine.disease
NPR2
Peptide Fragments
Endocrinology
Heart failure
Disease Progression
business
human activities
hormones, hormone substitutes, and hormone antagonists
Biomarkers
medicine.drug
Subjects
Details
- ISSN :
- 17520363
- Volume :
- 4
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Biomarkers in medicine
- Accession number :
- edsair.doi.dedup.....a69eed0d6079c8ac3fd6ff8625714f12