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Comparison of kidney paired donation transplantations with living related donor kidney transplantation: implications for national kidney paired donation program
- Source :
- Renal failure. 35(4)
- Publication Year :
- 2013
-
Abstract
- Kidney Paired Donation (KPD) is a rapidly growing modality for facilitating living related donor kidney transplantation (LRDKTx) for patients who are incompatible with their healthy, willing, and living donors. Data scarcity on the outcome of KPD versus LRDKTx prompted us to review our experience.This was a single-center study of 224 patients on regular follow-up, who underwent LRDRTx from January 2010 to June 2012 at our institute. The aim of this study was to compare short-term graft survival, patient survival and rejection rates of KPD (group 1, n = 34) with those of LRDKTx (group 2, n = 190). All the recipients received triple immunosuppression and thymoglobulin induction in KPD group. Kaplan-Meier curves were used for survival analysis. In group 1, mean recipient age was 35.5 ± 13.2 years, 29 were men and mean donor age was 44.4 ± 8.17 years, 10 were men. In group 2, mean recipient age was 29.1 ± 10 years, 155 were men and mean donor age was 47.5 ± 9.69 years, 74 were men. Mean human leukocyte antigen (HLA) matching in group 1 and 2 was 1 versus 3.2 (p0.05).One- and two-year patient survival showed no significant difference between the two groups (97.1%, 97.1% vs. 96.2%, 94.8%, respectively, p = 0.81). Death-censored graft survival also showed no significant difference between the two groups (97.1%, 97.1%, vs. 97.6%, 97.6%, p = 0.73). Acute rejection incidence was also similar (8.7% vs. 9.9%, p0.62).Our study showed similar graft survival, patient survival and rejection rates of KPD versus LRDKTx over 2 years post-transplantation, encouraging the use of this approach for national KPD program.
- Subjects :
- Adult
Graft Rejection
Male
medicine.medical_specialty
Tissue and Organ Procurement
Kidney Paired Donation
medicine.medical_treatment
Critical Care and Intensive Care Medicine
Donor age
Internal medicine
Living Donors
Medicine
Humans
Kidney transplantation
Survival analysis
Thymoglobulin
business.industry
Living related donor
Graft Survival
Patient survival
Immunosuppression
General Medicine
Middle Aged
medicine.disease
Kidney Transplantation
Survival Analysis
Surgery
Treatment Outcome
Nephrology
Female
business
Immunosuppressive Agents
Follow-Up Studies
Subjects
Details
- ISSN :
- 15256049
- Volume :
- 35
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Renal failure
- Accession number :
- edsair.doi.dedup.....a69c42db6d878897d77de8b4fc4b4c3c