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High HLA-F Expression Is a Poor Prognosis Factor in Patients with Nasopharyngeal Carcinoma
- Source :
- Analytical Cellular Pathology (Amsterdam), Analytical Cellular Pathology, Vol 2018 (2018)
- Publication Year :
- 2018
- Publisher :
- Hindawi, 2018.
-
Abstract
- Background and Aims. In patients with nasopharyngeal carcinoma (NPC), local treatment failure and distant metastasis contribute largely to poor outcomes. The nasopharynx is an important lymphoid tissue, and NPC tumourigenesis and development are partly attributed to immune system disorders. Human leukocyte antigen F (HLA-F) has shown a close correlation with NPC in many genome-wide association studies (GWASs). However, clinical studies rarely explore the relationship of HLA-F expression with the clinical parameters and outcomes in patients with NPC.Methods. In this study, we used immunohistochemistry to evaluate HLA-F expression in 74 paraffin-embedded NPC tissue sections and then analysed the association between HLA-F expression and clinical parameters and outcomes. The plasma concentration of soluble HLA-F (sHLA-F) in NPC patients and normal controls was also detected, via enzyme-linked immunosorbent assay (ELISA).Results. Low, moderate, and high HLA-F expression levels were observed in 47.3% (35/74), 35.1% (26/74), and 17.6% (13/74), respectively, of the tissue samples. HLA-F expression showed a significant correlation with local recurrence (p=0.037) and distant metastasis (p=0.024) and was also an independent factor for local recurrence-free survival (LRFS;p=0.016) and distant metastasis-free survival (DMFS;p=0.004). Although the mean concentration of plasma sHLA-F in the NPC patients was higher than that in the normal controls (13.63 pg/ml vs. 10.06 pg/ml), no statistical significance was observed (p=0.118).Conclusions. Our study provides the first evidence that high HLA-F expression is associated with NPC local recurrence and distant metastasis and may be regarded as a poor prognostic factor for NPC patients. Additional studies using larger sample sizes may be necessary to determine whether sHLA-F is a feasible NPC diagnostic indicator.
- Subjects :
- 0301 basic medicine
Oncology
Adult
Male
Cancer Research
medicine.medical_specialty
Article Subject
Human leukocyte antigen
Kaplan-Meier Estimate
Disease-Free Survival
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Immune system
Statistical significance
Internal medicine
otorhinolaryngologic diseases
Medicine
Humans
Neoplasm Metastasis
RC254-282
Aged
Proportional Hazards Models
Aged, 80 and over
Nasopharyngeal Carcinoma
QH573-671
business.industry
Proportional hazards model
Histocompatibility Antigens Class I
Case-control study
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Cell Biology
General Medicine
Middle Aged
medicine.disease
Prognosis
030104 developmental biology
Lymphatic system
Nasopharyngeal carcinoma
Nasopharyngitis
030220 oncology & carcinogenesis
Case-Control Studies
Molecular Medicine
Immunohistochemistry
Female
Neoplasm Recurrence, Local
Cytology
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 22107185 and 22107177
- Volume :
- 2018
- Database :
- OpenAIRE
- Journal :
- Analytical Cellular Pathology (Amsterdam)
- Accession number :
- edsair.doi.dedup.....a6981fc34494e8078fff36e5776855ac